Beta-2 transferrin: limitations of use as a clinical marker for perilymph

The Laryngoscope
M J LevensonS C Parisier

Abstract

Beta-2 transferrin is a protein marker that can be used in the clinical setting to reliably identify the presence of cerebrospinal fluid (CSF). Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph. This study investigates the use of a beta-2 transferrin assay as a method to identify the presence of perilymph. Twenty-two patients were enrolled in the study. Fluid samples were obtained intraoperatively and tested for the presence of beta-2 transferrin. As expected, four CSF samples collected were positive for beta-2 transferrin; however, four known perilymph samples collected from patients undergoing cochlear implantation were negative for beta-2 transferrin, seven of nine known perilymph samples obtained during stapedectomies were negative for beta-2 transferrin, and four of five samples collected during middle ear explorations for fistula were negative for beta-2 transferrin. With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting.

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Citations

Mar 20, 2002·Current Neurology and Neuroscience Reports·C G Maitland
Aug 6, 2015·The Journal of Laryngology and Otology·R BrarG Picken
Apr 14, 2000·The Laryngoscope·S D Rauch
Dec 24, 2004·Pediatric Annals·Ashley Schroeder, David H Darrow
Mar 23, 2018·Annals of the American Thoracic Society·Jisha JoshuaLaura E Crotty Alexander
Sep 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·John F McGuire, Begona Casado
Dec 31, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Gregor Bachmann-HarildstadOlav Klingenberg
Oct 13, 2020·Frontiers in Neurology·Brooke SarnaHamid R Djalilian

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