Beta 3 integrin expression on T cells from renal allograft recipients

Transplantation Proceedings
P WierzbickiA Górski

Abstract

Recent studies emphasize the paramount significance of beta 3 integrin in cell adhesion and homing, which may be particularly relevant in cancer progression and metastasis. In contrast, the presence and potential role of beta 3 on human T cells is practically unknown. We show that T cells can express significant amounts of alpha-beta 3 integrin (CD41/CD61), and the expression of alpha(v)-beta 3 (CD51/CD61) remains very low. T-cell beta 3 integrin is probably transferred by platelet-derived microparticles.

References

May 29, 2002·Experimental Hematology·Monika Baj-KrzyworzekaMariusz Z Ratajczak
Oct 23, 2004·International Journal of Cancer. Journal International Du Cancer·Anna Janowska-WieczorekMariusz Z Ratajczak

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