PMID: 7542940Apr 1, 1995Paper

Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin

Molecular Biology of the Cell
K Venstrom, L F Reichardt

Abstract

Integrins are major receptors used by cells to interact with extracellular matrices. In this paper, we identify the first ligands for the beta 8 family of integrins, presenting evidence that integrin heterodimers containing the beta 8 subunit mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin. A polyclonal antibody, anti-beta 8-Ex, was prepared to a bacterial fusion protein expressing an extracellular portion of the chicken beta 8 subunit. In nonreducing conditions, this antibody immunoprecipitated from surface-labeled embryonic dorsal root ganglia neurons a M(r) 100 k protein, the expected M(r) of the beta 8 subunit, and putative alpha subunit(s) of M(r) 120 k. Affinity-purified anti-beta 8-Ex strongly inhibited sensory neurite outgrowth on laminin-1, collagen IV, and fibronectin-coated substrata. Binding sites were identified in a heat-resistant domain in laminin-1 and in the carboxyl terminal, 40-kDa fibronectin fragment. On substrates coated with the carboxyl terminal fragment of fibronectin, antibodies to beta 1 and beta 8 were only partially effective alone, but were completely effective in combination, at inhibiting neurite outgrowth. Results thus indicate that the integrin beta 8 ...Continue Reading

References

Jan 1, 1991·Journal of Cell Science. Supplement·J Cohen, A R Johnson
Jan 1, 1991·Annual Review of Neuroscience·L F Reichardt, K J Tomaselli
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A D LanderL F Reichardt
Apr 1, 1994·Cell Adhesion and Communication·A M SheppardD C Dean
Apr 1, 1995·Molecular Biology of the Cell·U MüllerL F Reichardt
Sep 1, 1993·The Journal of Cell Biology·D T ShihC A Buck
Aug 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·R Timpl, J C Brown
Jul 1, 1994·Experimental Cell Research·E ForsbergS Johansson

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Citations

Apr 1, 1996·Molecular Neurobiology·L McKerracherC O Arregui
Jul 11, 2006·Clinical & Experimental Metastasis·Nicole VictorFaton H Agani
Feb 1, 1997·Brain Research. Brain Research Reviews·L Luckenbill-Edds
Mar 1, 1997·The International Journal of Biochemistry & Cell Biology·S K Powell, H K Kleinman
Oct 24, 1997·Development, Growth & Differentiation·C A GoodeC C Lambert
May 13, 2006·The Journal of Biological Chemistry·Sujata Lakhe-ReddyJeffrey R Schelling
Jun 15, 2004·Molecular Biology of the Cell·Alison L JannuziDanny L Brower
Mar 26, 2009·Current Opinion in Hematology·Joseph H McCarty
Mar 26, 2005·Journal of Clinical Pathology·K S NairR Chetty
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John M ProctorLouis F Reichardt
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J G Spector
Oct 10, 1998·Kidney International·H SugiyamaH Makino
Sep 21, 2000·Kidney International. Supplement·H MakinoN Kashihara
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Maria Laura Feltri, Lawrence Wrabetz
Jun 30, 2011·Developmental Neurobiology·Jonathan P MyersTimothy M Gomez
May 29, 2014·Journal of Biomedical Materials Research. Part a·S MruthyunjayaPadma Shastry
Apr 18, 2009·Cell Adhesion & Migration·Joseph H McCarty
Mar 23, 2011·Developmental Biology·Sólveig ThorsteinsdóttirFernanda Bajanca
Jan 1, 1997·Molecular and Cellular Neurosciences·S TangM T Filbin
Sep 24, 2011·Journal of Oncology·Stephan Niland, Johannes A Eble
Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M A Stepp
Nov 2, 2016·The Journal of Physical Chemistry. B·Mohd AfzalNitin Chattopadhyay
Nov 4, 2016·Scientific Reports·Jyoti GautamYao Yao
Feb 16, 2018·Biological Reviews of the Cambridge Philosophical Society·Bart NieuwenhuisJames W Fawcett
Aug 4, 2018·Biological Reviews of the Cambridge Philosophical Society·Abhijit Nirwane, Yao Yao
Jul 29, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Rita SilvaLouise E Reynolds
Sep 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S T QureshiD Malo

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