PMID: 8967518May 1, 1996Paper

Beta-adrenergic agonists attenuate fibroblast-mediated contraction of released collagen gels

The American Journal of Physiology
Tadashi MioStephen I Rennard

Abstract

The effects of beta-adrenergic agonists on fibroblast-mediated collagen gel contraction were investigated. beta-Agonists isoproterenol and epinephrine significantly attenuated fibroblast-mediated gel contraction in a concentration-dependent manner, whereas alpha-agonist norepinephrine had no effect. The biologically active form of isoproterenol, (-)-isoproterenol, was 10-fold more effective than the optical isoform, (+)-isoproterenol. beta-Antagonists sotalol and propranolol reversed the attenuation caused by 10(-7) M isoproterenol or epinephrine at the concentration of 10(-7) M or 10(-6) M, but the alpha-antagonist phentolamine did not. However, beta1- or beta2-specificity of these effects is not clear. Isobutyl methylxanthine augmented the effect of isoproterenol and also prolonged the duration. Two reagents which are known to increase intracellular adenosine 3',5'-cyclic monophosphate (cAMP), prostaglandin E2 and dibutyryl adenosine 3',5'-cyclic monophosphate, attenuated gel contraction in a concentration-dependent manner. These data suggest that the fibroblast-mediated collagen gel contraction can be modulated by beta-adrenergic agonists and that the effect depends on cAMP.

Citations

Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·X D LiuS I Rennard
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tadashi KohyamaStephen I Rennard
Sep 23, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·C M SköldS I Rennard
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·T MioS I Rennard
Mar 30, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaoqiu LiuRennolds S Ostrom
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·John R SpurzemTodd A Wyatt
Oct 4, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Vlad C SandulachePatricia A Hebda
Jan 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·H MikiT Izumi
Sep 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Tadashi KohyamaStephen I Rennard
Apr 3, 2010·BioTechniques·Roger IlaganJohn Ludlow

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