Beta-adrenergic antagonists in hypertension: a review of the evidence

The Annals of Pharmacotherapy
T Scott WarmackAmy M Franks

Abstract

To evaluate the effects of beta-adrenergic antagonist therapy on cardiovascular and cerebrovascular outcomes in the treatment of hypertension. Literature searches were conducted using MEDLINE (1966-August 2009), International Pharmaceutical Abstracts (1970-August 2009), and Cochrane Database of Systematic Reviews (until third quarter 2009) to locate clinical trials and meta-analyses comparing beta-blocker therapy with placebo or other antihypertensive agents in patients with hypertension. Bibliographies from relevant research and review articles were reviewed for additional references. All English-language articles identified from the data sources were reviewed. Articles describing original research with cardiovascular or cerebrovascular outcomes and/or death as either primary or secondary endpoints were included. Articles describing the use of beta-blocker therapy for conditions other than hypertension were not included. Five placebo-controlled studies and 10 active-controlled studies were reviewed. In addition, 11 meta-analyses were evaluated. Placebo-controlled trials of beta-blockers in hypertension provide evidence of reduced risk for stroke, cardiovascular events, and heart failure. Only 2 studies comparing beta-blockers ...Continue Reading

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Citations

Aug 30, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Abhijat KitchluAmit X Garg
Apr 3, 2014·Journal of Molecular Signaling·Shujuan GaoHsien-Yu Wang
Jun 26, 2010·Diabetology & Metabolic Syndrome·Sanjay KalraNavneet Agrawal
Apr 2, 2014·The Annals of Pharmacotherapy·Toni L Ripley, Joseph J Saseen
Jun 22, 2018·Omics : a Journal of Integrative Biology·Nicholas Ekow ThomfordCollet Dandara
Oct 6, 2018·The Journal of Clinical Hypertension·Brent EganSofia Lombera

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