PMID: 8582390Sep 1, 1995Paper

Beta adrenergic blockade does not improve effort tolerance in patients with mitral stenosis in sinus rhythm

European Heart Journal
J J PatelA S Mitha

Abstract

This study was designed to assess the effects of beta-blockade on cardiopulmonary exercise performance in symptomatic patients with tight mitral stenosis in sinus rhythm. The role of beta-blockers in these patients has been controversial and assessment of effort tolerance using treadmill exercise time has produced conflicting results. Nineteen patients with isolated symptomatic (New York Heart Association class II or III) mitral stenosis received a beta-blocker (acebutalol or atenolol) or matching placebo for one week each in a randomized double-blind crossover fashion. Exercise on a treadmill with real time gas exchange analysis was performed six times over 4 weeks in each patient. The test was further repeated once within a week of percutaneous mitral valvotomy. Heart rate at rest and during peak exercise was significantly lower with beta-blockade compared to control state or placebo treatment. Mean peak oxygen consumption did not differ significantly between treatment groups. When patients were arbitrarily classified into those with (group I, heart rate < or = 130.min-1) and those without (group II, heart rate > or = 131.min-1) adequate beta-blockade, there was a significant difference in peak VO2. The peak VO2 for group I: ...Continue Reading

Citations

Dec 6, 2017·Medicine and Science in Sports and Exercise·David Montero, Andreas J Flammer
Jan 16, 2014·International Journal of Clinical Practice·R Ray, J Chambers
Feb 9, 2021·The Annals of Pharmacotherapy·Arden R Barry, Erica H Z Wang

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