Jan 1, 1976

beta-Adrenergic blockade reduces the severity of acute renal failure in rats

Proceedings of the European Dialysis and Transplant Association
A IainaH E Eliahou

Abstract

Propranolol administration in the hypoxic model of acute renal failure (ARF) in rats has reduced plasma renin activity (PRA) and uraemia as compared to untreated controls. P113 has no effect on uraemia but increased PRA in ARF. A combination of both drugs is no more effective in reducing uraemia than propranolol alone. These results support the view that beta-adrenergic blockade by propranolol reduces the severity of ARF by preventing the post-hypoxic release of renin.

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Mentioned in this Paper

Kidney Failure, Acute
Ren
Uremia
Anoxemia
Renin Measurement
Angiotensin II, Val(5)-
STAT2 wt Allele
Propranolol
Renin
REN gene

About this Paper

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