PMID: 3746697May 1, 1986Paper

Beta-adrenergic inhibition of bovine mesenteric lymphatics

The Journal of Physiology
J M AllenN G McHale

Abstract

The beta-action of catecholamines on lymphatic smooth muscle was studied by observing the effect of isoprenaline on electrical and mechanical activity in the double sucrose-gap. Action potentials and phasic contractions evoked by depolarizing pulses were abolished within 2 min of drug addition. Isoprenaline hyperpolarized the membrane and increased membrane conductance. Tetraethylammonium (10 mM) did not itself affect membrane resistance but reduced the hyperpolarization and the increase in conductance caused by isoprenaline. Removal of K+ from the external solution reduced membrane conductance and increased the hyperpolarization due to isoprenaline. When the NaCl content of Krebs solution was replaced with LiCl or choline chloride, isoprenaline no longer blocked action potential firing and its effects on phasic contractions and membrane conductance were reduced. In contrast, ouabain (10(-5) M) did not block the effect of isoprenaline on membrane potential and membrane conductance. These results suggest that beta-adrenergic inhibition of lymphatic smooth muscle involves an increase in an outward K+ current, though an additional metabolic effect cannot be ruled out.

Citations

Mar 17, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Anatoliy A Gashev, David C Zawieja
Jan 1, 1989·Microvascular Research·N G McHale, K D Thornbury
Aug 15, 1997·The Journal of Physiology·K D CottonK D Thornbury
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ilia FerrusiPierre-Yves von der Weid
Dec 19, 2017·Lymphatic Research and Biology·Scott D ZawiejaMichael J Davis
Feb 1, 1988·Pflügers Archiv : European journal of physiology·J M Allen, N G McHale
Jun 19, 2009·Lymphatic Research and Biology·David C Zawieja
Nov 14, 2012·Nature Reviews. Rheumatology·Georg Pongratz, Rainer H Straub
May 15, 2013·American Journal of Physiology. Heart and Circulatory Physiology·R M DongaonkarR H Stewart
May 29, 2003·British Journal of Pharmacology·Alice K Chan, Pierre-Yves von der Weid
Aug 21, 2021·Cardiovascular Research·Peter S RussellAnthony R J Phillips

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