Beta-adrenergic receptor blocking drugs in spontaneous hypertension

The American Journal of Medicine
J V Levy

Abstract

Eleven beta-adrenergic receptor blocking agents and derivatives were evaluated for their ability to affect systolic arterial blood pressure and pulse rate in unanesthetized, male spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto (WKY) controls. Animals ranged from 7 to 76 weeks of age. The subcutaneous injection of 5 and 45 mg/kg metoprolol in 52 to 64 week old SHRs and 45 mg/kg twice a day to 26 to 29 week old SHRs produced a significant decrease in blooc pressure. The subcutaneous injection of pindolol (0.1 and 1.0 mg/kg) produced a greater and more consistent depressor effect in mature SHRs. The subcutaneous administration of sotalol (100 mg/kg) and alprenolol (20 mg/kg) resulted in a depressor action which was significant 120 minutes after injection of the drug. In the doses used, propranolol, oxprenolol, 4-hydroxypropranolol and K9-1366 produced pressor effect in SHRs. Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs. Practolol, dextro-propranolol and KO-1313 had no effect on blood pressure in the doses used. Propranolol, pindolol, metoprolol, dextro-propranolol, 4-hydroxypropranolol, practolol, oxprenolol, KO-1366 and KO-1313 produced no significant effects on blood...Continue Reading

References

Oct 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·H H Parving, F Gyntelberg
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·A ScriabineN R Bohidar
Mar 1, 1974·Japanese Heart Journal·Y Numao, J Iriuchijima
Apr 1, 1974·Japanese Journal of Pharmacology·J Yamamoto, A Sekiya
Dec 1, 1974·The Journal of Clinical Investigation·M A WeberJ M Gain
Jan 15, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H Karppanen
Dec 1, 1972·Circulation Research·S SenF M Bumpus
Jun 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·J V Levy, V Richards
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Nov 1, 1970·British Journal of Pharmacology·A M Barrett, J Carter
Sep 1, 1971·British Journal of Pharmacology·J D Fitzgerald, S R O'Donnell
Dec 1, 1974·Circulation Research·W B Campbell, S Sen
Jan 1, 1974·Clinical and Experimental Pharmacology & Physiology·G J Dusting, M J Rand
Apr 1, 1973·Minerva cardioangiologica·B MagnaniM Sanguinetti
Oct 1, 1973·Canadian Journal of Physiology and Pharmacology·I VávraE Greselin
Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·A J TobiaJ Y Lee
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·W De JongA Sjoerdsma
Jul 1, 1972·Circulation Research·E D FreisM Mathews
Nov 1, 1972·Journal of Neurosurgery·V BenesD Obrovská
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

Citations

Feb 15, 1978·European Journal of Pharmacology·C RicherJ F Giudicelli
Aug 1, 1989·Journal of Molecular and Cellular Cardiology·R J Tomanek
Jan 1, 1979·General Pharmacology·R E Buckingham, T C Hamilton
Apr 1, 1990·Clinical and Experimental Pharmacology & Physiology·A C Yong, G W Boyd
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·P J ManhemJ I Robertson
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·J YamamotoM Nakai
Feb 1, 1980·The Journal of Pharmacy and Pharmacology·J F SmitsH A Struyker-Boudier
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·C RicherJ F Giudicelli

Related Concepts

Adrenergic beta-Antagonists
Senility
Aptina
Metazoa
Diastolic Blood Pressure
Hypertensive Disease
Betalok
Trasicor
Visken
Dalzic

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.