PMID: 6142847Jan 1, 1984

Beta-adrenergic receptor subtypes in iris-ciliary body of rabbits

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
C J SchmittN N Share

Abstract

Direct comparison of drug interaction with intraocular relative to extraocular beta-adrenergic receptors was used to test the hypothesis that the receptors in ocular tissues are of the beta 2-subtype. Potencies for the displacement of 3H-dihydroalprenolol radioligand binding to membranes obtained from rabbit-iris ciliary bodies by beta-adrenoceptor agonists was in the order: isoproterenol greater than or equal to epinephrine greater than salbutamol greater than terbutaline greater than tazolol greater than norepinephrine. Similar radioligand displacement by beta-adrenoceptor antagonists was in the order of potency: alprenolol greater than or equal to bupranolol = oxprenolol = timolol = propranolol greater than ICI 118,551 = IPS 339 much greater than betaxolol greater than metoprolol. Finally, for the above beta-adrenoceptor antagonists, a highly significant correlation was obtained for displacement of radioligand to ocular tissues (pKi values) relative to antagonism (pA2 values) of isoproterenol-induced guinea-pig tracheal relaxation but not guinea-pig atrial chronotropic effects. Consequently, the above three observations reinforce the notion that rabbit-iris ciliary bodies contain beta-adrenergic receptors predominantly of th...Continue Reading

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Citations

Aug 1, 1987·Documenta Ophthalmologica. Advances in Ophthalmology·G NiemeyerU Gerber
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P Gautheron, M F Sugrue
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M F SugrueM P Viader
Jan 1, 1989·Pharmacology & Therapeutics·M F Sugrue
Apr 30, 2003·Expert Opinion on Biological Therapy·Surajit DeyAshim K Mitra
Nov 1, 1988·The Journal of Pharmacy and Pharmacology·J A Nathanson, E J Hunnicutt

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Alprenolol Hydrochloride
Ciliary Body
Dihydroalprenolol
Cavia porcellus
Right Atrial Structure
Iris (Eye)
Novodrin
Radioligand Assay

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