Beta-Adrenergic receptors and catecholamine-sensitive adenylate cyclase of the human placenta

The Journal of Clinical Endocrinology and Metabolism
J A WhitsettM Costello


Beta-Adrnergic receptor and beta-adrenergic sensitive adenylate cyclase were demonstrated in membrane fractions of human placenta. Placental membranes from normal term pregnancies bound the beta-adrenergic antagonist (-)[3H]dihydroalprenolol to a single saturable class of sites (Kd = 2.31 +/- 0.23 nM; n = 9; maximal capacity, 112 +/- 9 fmol/mg). Competition for binding was stereoselective for (-)isomers of propranolol, and beta-adrenergic agonists displayed competition for the placental receptor in the order (-)isoproterenol greater than (-)epinephrine greater than (-)norepinephrine, typical of a beta 2 type receptor. Beta-Adrenergic receptor was present in placental tissue as early as 10 weeks gestational age, and binding capacity decreased slightly with advancing gestation. [3H]Dihydroalprenolol binding was coupled to epinephrine-stimulated adenylate cyclase activity throughout gestation. The subcellular distribution of both beta-adrenergic receptors and epinephrine-stimulated adenylate cyclase suggest their localization primarily in nonbrush border membrane fractions, presumably from plasma membranes more closely related to the fetal rather than to the maternal circulation. Epinephrine-sensitive adenylate cyclase was not pre...Continue Reading


Mar 18, 2005·Pflügers Archiv : European journal of physiology·P F SpeakeC P Sibley
Nov 21, 1993·Biochimica Et Biophysica Acta·S ByrneC P Sibley
Jul 1, 1986·Journal of Steroid Biochemistry·C L HellerA F De Nicola
Jan 1, 1990·Life Sciences·M S AhmedM E Eldefrawi
May 1, 1989·Molecular and Cellular Endocrinology·M Tencé, A Petit
Jun 25, 1984·Biochimica Et Biophysica Acta·P Truman, H C Ford
Apr 18, 2001·Molecular and Cellular Endocrinology·R IshimuraK Shiota
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·A J Conley, J I Mason
Jul 1, 1982·The New England Journal of Medicine·H J Motulsky, P A Insel
Oct 1, 1994·Journal of Autonomic Pharmacology·J A de AlmeidaF Amenta
Jan 1, 1986·Journal of Perinatal Medicine·G Falkay, L Kovács
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Feb 15, 1984·American Journal of Obstetrics and Gynecology·G C Di RenzoJ E Bleasdale
Mar 1, 1992·Placenta·M M JacobsN P Illsley
Apr 1, 1982·Placenta·L MilewichP C MacDonald
Nov 15, 1980·American Journal of Obstetrics and Gynecology·S N Caritis, A J Zeleznik
Feb 15, 1981·American Journal of Obstetrics and Gynecology·J F PadburyD A Fisher
Mar 1, 1983·Clinics in Endocrinology and Metabolism·B B Hoffman
Oct 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A O AisienG E Imade
Apr 1, 1988·The Anatomical Record·A SprecaA Angelini
Jun 1, 1982·Journal of Autonomic Pharmacology·D B BarnettS R Nahorski
Apr 1, 1990·Journal of Endocrinological Investigation·F PetragliaS Angioni
Feb 1, 1989·Journal of Endocrinological Investigation·J M Lopez, C B Fardella
Jun 1, 1987·Journal of Endocrinological Investigation·E R Barnea, F Naftolin
May 1, 1994·Journal of Receptor Research·G FalkayL Kovács
Apr 1, 1981·The American Journal of Physiology·J A WhitsettJ J Moore
Jul 6, 1981·Brain Research·J A WhitsettJ J Moore
Sep 1, 1992·Placenta·J F StraussM E Gåfvels
Nov 1, 1987·Placenta·R L Ingermann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.