Beta-Adrenergic receptors and catecholamine-sensitive adenylate cyclase of the human placenta

The Journal of Clinical Endocrinology and Metabolism
J A WhitsettM Costello

Abstract

Beta-Adrnergic receptor and beta-adrenergic sensitive adenylate cyclase were demonstrated in membrane fractions of human placenta. Placental membranes from normal term pregnancies bound the beta-adrenergic antagonist (-)[3H]dihydroalprenolol to a single saturable class of sites (Kd = 2.31 +/- 0.23 nM; n = 9; maximal capacity, 112 +/- 9 fmol/mg). Competition for binding was stereoselective for (-)isomers of propranolol, and beta-adrenergic agonists displayed competition for the placental receptor in the order (-)isoproterenol greater than (-)epinephrine greater than (-)norepinephrine, typical of a beta 2 type receptor. Beta-Adrenergic receptor was present in placental tissue as early as 10 weeks gestational age, and binding capacity decreased slightly with advancing gestation. [3H]Dihydroalprenolol binding was coupled to epinephrine-stimulated adenylate cyclase activity throughout gestation. The subcellular distribution of both beta-adrenergic receptors and epinephrine-stimulated adenylate cyclase suggest their localization primarily in nonbrush border membrane fractions, presumably from plasma membranes more closely related to the fetal rather than to the maternal circulation. Epinephrine-sensitive adenylate cyclase was not pre...Continue Reading

Citations

Mar 18, 2005·Pflügers Archiv : European journal of physiology·P F SpeakeC P Sibley
Nov 21, 1993·Biochimica Et Biophysica Acta·S ByrneC P Sibley
Jul 1, 1986·Journal of Steroid Biochemistry·C L HellerA F De Nicola
Jan 1, 1990·Life Sciences·M S AhmedM E Eldefrawi
May 1, 1989·Molecular and Cellular Endocrinology·M Tencé, A Petit
Jun 25, 1984·Biochimica Et Biophysica Acta·P Truman, H C Ford
Apr 18, 2001·Molecular and Cellular Endocrinology·R IshimuraK Shiota
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·A J Conley, J I Mason
Jul 1, 1982·The New England Journal of Medicine·H J Motulsky, P A Insel
Oct 1, 1994·Journal of Autonomic Pharmacology·J A de AlmeidaF Amenta
Jan 1, 1986·Journal of Perinatal Medicine·G Falkay, L Kovács
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Feb 15, 1984·American Journal of Obstetrics and Gynecology·G C Di RenzoJ E Bleasdale
Mar 1, 1992·Placenta·M M JacobsN P Illsley
Apr 1, 1982·Placenta·L MilewichP C MacDonald
Nov 15, 1980·American Journal of Obstetrics and Gynecology·S N Caritis, A J Zeleznik
Feb 15, 1981·American Journal of Obstetrics and Gynecology·J F PadburyD A Fisher
Mar 1, 1983·Clinics in Endocrinology and Metabolism·B B Hoffman
Oct 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A O AisienG E Imade
Apr 1, 1988·The Anatomical Record·A SprecaA Angelini
Jun 1, 1982·Journal of Autonomic Pharmacology·D B BarnettS R Nahorski
Apr 1, 1990·Journal of Endocrinological Investigation·F PetragliaS Angioni
Feb 1, 1989·Journal of Endocrinological Investigation·J M Lopez, C B Fardella
Jun 1, 1987·Journal of Endocrinological Investigation·E R Barnea, F Naftolin
May 1, 1994·Journal of Receptor Research·G FalkayL Kovács
Apr 1, 1981·The American Journal of Physiology·J A WhitsettJ J Moore
Jul 6, 1981·Brain Research·J A WhitsettJ J Moore
Sep 1, 1992·Placenta·J F StraussM E Gåfvels
Nov 1, 1987·Placenta·R L Ingermann

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