PMID: 6167288Jun 11, 1981Paper

beta-Adrenergic receptors stimulated peroxidase secretion from rat lacrimal gland

Biochimica Et Biophysica Acta
Z Y FriedmanZ Selinger

Abstract

Incubation of rat extraorbital lacrimal gland slices with the beta-agonist isoproterenol caused peroxidase secretion but no K+ release. The peroxidase secretion was inhibited by propranolol. Addition of dibutyryl cyclic AMP or adenosine 3'5'-cyclic phosphorothioate to lacrimal slices produced peroxidase secretion at a higher rate than that obtained with optimal concentration of isoproterenol. Methyl isobutylxanthine is also a strong stimulator of peroxidase secretion. Peroxidase activity was determined by a modified sensitive guaiacol method. Membrane fraction of lacrimal cells was shown to contain an isoproterenol-stimulated adenylate cyclase activity. It is therefore suggested that there is a beta-adrenergic receptor in the rat lacrimal gland and that its stimulation causes activation of an adenylate cyclase which leads to peroxidase secretion.

References

Nov 11, 1978·The American Journal of Physiology·J W PutneyB A Leslie
Jan 1, 1976·The American Journal of Physiology·G Keryer, B Rossignol
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·Z SelingerM Schramm
Jan 1, 1967·British Journal of Pharmacology and Chemotherapy·J M Elsby, H Wilson

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Citations

Jan 1, 1984·Pflügers Archiv : European journal of physiology·G T Pearson, O H Petersen
Nov 1, 1987·Experimental Eye Research·M M CrippsM H Welch
Aug 8, 1998·Journal of the Autonomic Nervous System·C E DraperJ Singh
Mar 1, 1986·Current Eye Research·B B BrombergM H Welch
Apr 1, 1985·Current Eye Research·D A DarttG W Sharp
Jan 1, 1984·The American Journal of Physiology·P MauduitB Rossignol
May 1, 1986·The American Journal of Physiology·P MauduitB Rossignol
Apr 17, 1990·Molecular and Cellular Endocrinology·Y Salomon

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