Beta-adrenergic responsiveness of the gastrointestinal tract in diabetic rats

Pharmacology & Toxicology
Y OztürkN Yildizoğlu-ari

Abstract

Recently, decreased gastrointestinal beta-adrenergic responses in experimental diabetes have been demonstrated. Gastrointestinal responses to beta-adrenoceptor agonists are impaired in both insulin-dependent and non-insulin-dependent diabetic rat. Insulin treatment improves the impaired gastrointestinal beta-adrenergic responsiveness of diabetic rats. The improvement seen with insulin treatment on beta-adrenergic responsiveness is closely related to protein biosynthesis. The decreased beta-adrenergic responses in diabetic rat gastrointestinal tract seem to result from a decrease in the number of beta-adrenoceptors. It is most likely that the decreased gastrointestinal beta-adrenergic responsiveness is related to an impairment in the turnover of beta-adrenoceptors as a consequence of diabetes and that insulin has a beneficial effect on the impaired receptor turnover.

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Citations

Jan 15, 1996·Molecular and Cellular Endocrinology·S AydinA T Ozçelikay
Sep 1, 1996·Journal of Diabetes and Its Complications·Y OztürkN Yildizoğlu-ari
Jun 27, 2003·European Journal of Pharmacology·Koji NobeKazutaka Momose

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