PMID: 9431854Feb 12, 1998Paper

Beta-adrenergic stimulation of renin expression in vivo

Journal of Hypertension
S R HolmerArmin Kurtz

Abstract

To characterize the effect of beta-adrenergic activation on renal production of renin in the intact organism. Renal expression of renin [renin messenger RNA (mRNA)], plasma renin activity (PRA), inactive renin level, intrarenal renin distribution (immunohistochemistry), and the time course of activation of renin as well as hemodynamic parameters were determined during the subcutaneous infusion of isoproterenol (ISO) into rats. To examine whether beta-adrenergic activation of the renin system is modulated by the rate of salt intake rats were fed diets with normal, low and high salt contents. Systolic blood pressure was not altered. PRA was elevated as much as fourfold after 40 h of ISO infusion. Although renal renin mRNA levels were elevated dose-dependently up to 4.2-fold, no significant recruitment of renin-containing cells could be detected. The time course of PRA revealed a marked transient rise of PRA during 6 h of ISO infusion with a subsequent decline. Inactive renin level was elevated during 3 to 18 h of ISO infusion. In contrast, renin mRNA level increased steadily with a lag phase of 3 h. Infusion of ISO increased PRA and renin mRNA level under a high-salt diet, but had no additional effect either on PRA or on renin mR...Continue Reading

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Citations

Jun 27, 2012·Pflügers Archiv : European journal of physiology·Ulla G FriisBoye L Jensen
Apr 20, 2000·European Journal of Pharmacology·J BlancJ L Elghozi
Apr 5, 2000·International Journal of Cardiology·A C TeismanW H van Gilst
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May 3, 2006·Biological & Pharmaceutical Bulletin·Tomoyuki KondaHiroshi Yamamoto
Feb 11, 2015·Pharmacology & Therapeutics·Koichiro Kuwahara, Takeshi Kimura
Nov 13, 2012·Journal of Neuroendocrinology·H N BoydaA M Barr
Jan 11, 2017·American Journal of Physiology. Renal Physiology·Charlotte BuckleyJohn J Mullins
Aug 10, 2006·The Journal of Biological Chemistry·David J AdamsBrian J Morris
Mar 23, 2007·American Journal of Physiology. Renal Physiology·Corina MatzdorfKlaus Höcherl
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Björn NeubauerCharlotte Wagner
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·C Wagner, A Kurtz
Jan 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birgül Kurt, Armin Kurtz
Dec 8, 2007·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Veena RaizadaJeffrey Griffith
Mar 11, 2011·American Journal of Physiology. Renal Physiology·Björn NeubauerCharlotte Wagner
Sep 16, 2021·Journal of Neurochemistry·Yu HasegawaMotohiro Morioka

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