PMID: 9166732Jun 1, 1997Paper

beta-Adrenergic stimulation promotes homocysteic acid release from astrocyte cultures: evidence for a role of astrocytes in the modulation of synaptic transmission

Journal of Neurochemistry
K Q DoP J Magistretti

Abstract

The sulfur-containing amino acid homocysteic acid (HCA) is present in and released from nervous tissue, exerting excitatory effects on neurons by predominantly activating NMDA receptors. It is interesting that HCA appears to be exclusively localized in glial cells, not in neurons. This profile of glial localization and excitatory action on neurons has led to the hypothesis that HCA could participate in intercellular communication in the brain as a "gliotransmitter." To test this hypothesis further, we searched for specific, receptor-mediated stimuli that could induce release of HCA from cultured astrocytes. For this reason we tested the effect of noradrenaline and vasoactive intestinal peptide, two transmitters known to interact with specific receptors on astrocytes, on the release of HCA from these cells. Noradrenaline and the beta-adrenergic agonist isoproterenol induced an efflux of HCA from astrocyte cultures. Further stressing the beta-adrenergic mediation of this effect is the blockade by atenolol of the HCA release evoked by isoproterenol. The stimulation of HCA release from astrocytes was not observed with the alpha-noradrenergic agonist methoxamine and with vasoactive intestinal peptide. These results taken together fu...Continue Reading

Citations

Feb 25, 2006·The Journal of Comparative Neurology·Yasmin NasserKeith A Sharkey
Jan 18, 2008·Journal of Human Hypertension·A PoduriM Khullar
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S Kasparov, A G Teschemacher
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S ZerarkaP J Magistretti
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Qi ShiBryan L Roth
Nov 29, 2002·The Journal of Physiology·Johannes Brockhaus, Joachim W Deitmer
Dec 17, 2020·Frontiers in Neurology·Quirijn P VerhoogErwin A van Vliet
Jul 6, 2000·Progress in Neurobiology·G Carmignoto
Aug 23, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aron M Troen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.