PMID: 6104793Apr 1, 1980Paper

beta-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: dissociation of stimulation and blockade

Naunyn-Schmiedeberg's Archives of Pharmacology
A J Kaumann, J R Blinks

Abstract

The cardiac stimulant actions of nine beta-adrenoceptor blocking agents were examined in kitten papillary muscles and in isolated atria of kittens and guinea pigs to determine to what extent these drugs behaved as classical partial agonists. In many ways the agents do appear to comprise a spectrum of partial agonists with widely differing efficacies. However, in one respect the actions of some of the beta-blockers did not fit into the classical mold. Several beta-blockers were found to exert stimulant effects only in concentrations appreciably higher than those required for substantial beta-adrenoceptor blockade. These observations suggest that more than one type of beta-adrenoceptor may be involved in the production of sympathomimetic effects on cardiac muscle.

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Citations

Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·T H MorrisA J Kaumann
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·V HomburgerJ Bockaert
Jun 1, 1993·Cardiovascular Drugs and Therapy·J D Fitzgerald
Jun 1, 1991·Cardiovascular Drugs and Therapy·A J Kaumann
Jul 5, 1994·Biochemical Pharmacology·B N WuI J Chen
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Apr 25, 1989·European Journal of Pharmacology·P Y MarieR J Royer
Feb 26, 1991·European Journal of Pharmacology·S OchiS Imai
Jan 11, 1996·European Journal of Pharmacology·R M MayersB R Holloway
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Jan 1, 1983·General Pharmacology·B J Clark, A Bertholet
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Mar 1, 1992·General Pharmacology·R A Bond, P M Vanhoutte
Jul 1, 1994·General Pharmacology·B N WuI J Chen
Aug 1, 1996·British Journal of Pharmacology·A J Kaumann, P Molenaar
Mar 1, 1988·Journal of Pharmacological Methods·G Pöch, I Zimmermann
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·J D Fitzgerald
May 27, 2008·Pharmacology & Therapeutics·Alberto J Kaumann, Peter Molenaar
Jan 1, 1993·The American Journal of Cardiology·S A StrickbergerP L Friedman
Nov 1, 1984·The American Journal of Emergency Medicine·A Heath
Jan 1, 1987·British Journal of Clinical Pharmacology·W H Aellig, B J Clark
Jan 1, 1982·British Journal of Clinical Pharmacology·B J ClarkA Bertholet
Sep 14, 1993·Biochemical Pharmacology·A Elnatan, F Mitchelson
Mar 25, 2011·Trends in Pharmacological Sciences·Jillian G BakerRoger J Summers
May 1, 1987·International Journal of Cardiology·R J Northcote
May 22, 2004·Journal of Pharmacological Sciences·Maura FloreaniPaola Dorigo
Jul 1, 1996·Journal of Cardiovascular Pharmacology·Y T LinI J Chen

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