PMID: 369646Jan 20, 1979Paper

Beta-adrenoceptor-blocking drugs and blood sugar control in diabetes mellitus

British Medical Journal
A D WrightP H Poole

Abstract

The effects on diabetic control of the relative cardioselective beta-blocker metoprolol and the non-selective drug propranolol were compared in 20 hypertensive diabetic patients receiving diet alone or diet and oral hypoglycaemic agents. Each drug was given for one month in a double-blind, cross-over study. Fasting, noon, and mid-afternoon blood sugar concentrations rose by 1.0-1.5 mmol/l (18-27 mg/100 ml). The rise with propranolol was not significantly greater than with metoprolol. In a few patients the rise was clinically important. The small overall change observed in diabetic control should not deter the use of beta-blockers in non-insulin-dependent diabetics, provided control is carefully monitored at the onset of treatment.

Citations

May 1, 1988·Baillière's Clinical Endocrinology and Metabolism·D A RobertsonM Nattrass
Jul 1, 1985·Postgraduate Medical Journal·A D Struthers
Jan 1, 1984·European Journal of Clinical Pharmacology·K TöttermanF Fyhrquist
Jan 1, 1984·European Journal of Clinical Pharmacology·L A FerraraM Mancini
Jan 1, 1987·European Journal of Clinical Pharmacology·G Olsson, N Rehnqvist
Jan 1, 1989·European Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Jan 1, 1983·Pharmacology & Therapeutics·M J Kendall, L Beeley
Jan 1, 1981·Pharmacology & Therapeutics·B L Furman
Jan 1, 1986·Current Medical Research and Opinion·D M FraserJ D Poloniecki
Jun 15, 2006·Mayo Clinic Proceedings·Craig S StumpJames R Sowers
Jul 1, 2008·Journal of the American Society of Hypertension : JASH·Melvin R Hayden, James R Sowers
Nov 9, 2015·Autonomic Neuroscience : Basic & Clinical·Ana Barbara Alves-WagnerUbiratan Fabres Machado
Aug 28, 2010·Pharmacotherapy·Hrishikesh A NavareJulie A Johnson
Nov 1, 1990·Survey of Ophthalmology·S L GerberD C Brater
Jul 1, 1980·British Journal of Clinical Pharmacology·R WilkinsonJ D Harry
Aug 1, 1986·British Journal of Clinical Pharmacology·C G SempleK R Paterson
Oct 5, 1988·The American Journal of Cardiology·L AndrénH Wadenvik
Mar 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·W Y Tse, M Kendall
Sep 27, 1979·The New England Journal of Medicine·J Koch-Weser
Dec 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·S CapewellA L Muir
Nov 1, 1981·Clinics in Endocrinology and Metabolism·J R Sowers, M L Tuck
Mar 17, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·N YounisJ P Vora
Dec 1, 1989·European Journal of Clinical Investigation·M LaaksoL Mykkänen
Jun 1, 1986·Journal of Clinical and Hospital Pharmacy·M J KendallM C Chellingsworth
Sep 1, 1982·Journal of Clinical and Hospital Pharmacy·P L Weissberg
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·M J Kendall, S R Smith
Mar 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·J S CorcoranJ S Yudkin
Jul 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·C M Ritchie, A B Atkinson
Mar 5, 2003·Pharmacological Reviews·Máire E Doyle, Josephine M Egan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.