Beta-adrenoceptor blocking properties and cardioselectivity of M & B 17,803A

British Journal of Pharmacology
B BasilD R Maxwell

Abstract

1. The beta-adrenoceptor blocking properties of (+/-)-1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride (M&B 17,803A) have been compared with those of practolol and propranolol in the guinea-pig, cat and dog.2. Following either intravenous or oral administration in the cat or dog, M&B 17,803A and practolol had similar potency in antagonizing isoprenaline-induced tachycardia and both showed cardioselectivity, but both were less potent than propranolol.3. M&B 17,803A and practolol had approximately one hundredth the intravenous potency of propranolol in increasing the severity of anaphylactic bronchospasm in the conscious sensitized guinea-pig.4. M&B 17,803A possessed less marked intrinsic sympathomimetic activity than practolol but, like propranolol, it had significant local anaesthetic properties and increased the refractory period of rabbit isolated atria.

References

May 15, 1971·Lancet·I Roetscher
Dec 1, 1965·British Journal of Pharmacology and Chemotherapy·J W BLACKR G Shanks
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Nov 1, 1970·British Journal of Pharmacology·A M Barrett, J Carter
Feb 27, 1971·British Medical Journal·D J ColtartD G Shand
Dec 1, 1967·European Journal of Pharmacology·M W McCullochM J Rand
Jun 1, 1956·British Journal of Pharmacology and Chemotherapy·C BIANCHI
Jun 1, 1946·British Journal of Pharmacology and Chemotherapy·G S DAWES

Citations

Mar 17, 1978·European Journal of Clinical Pharmacology·G CoccoF Follath
May 21, 1979·European Journal of Clinical Pharmacology·K L WoodsR J Grieve
Oct 14, 1977·European Journal of Clinical Pharmacology·L HanssonM Holm
Dec 15, 1972·Experientia·K R Woolridge
May 1, 1982·Veterinary Research Communications·N G Gregory, L J Wilkins
Nov 1, 1974·European Journal of Pharmacology·S Zakhari
Nov 1, 1974·European Journal of Pharmacology·E J Mylecharane, C Raper
May 7, 1982·European Journal of Pharmacology·B Basil, R Jordan
Jun 24, 1986·European Journal of Pharmacology·N LavanchyA Rossi
Jan 1, 1988·Pharmacology & Therapeutics·J W UpwardC F George
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Midol-MonnetJ Barre
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S ShibataN Satake
Oct 1, 1975·British Journal of Clinical Pharmacology·C Skinner, K N Palmer
Aug 1, 1975·British Journal of Clinical Pharmacology·H H Harms, J Van der Meer
Feb 1, 1976·British Journal of Clinical Pharmacology·D O GibbonsS Pinder
Oct 1, 1979·British Journal of Clinical Pharmacology·J F GiudicelliC Richer
Oct 1, 1978·British Journal of Clinical Pharmacology·M A MartinA J Smith
Aug 9, 1980·British Medical Journal·M K JonesJ Birtwell
Apr 1, 1981·Postgraduate Medical Journal·M K JonesM Lewis
Jan 1, 1980·Pharmacology & Therapeutics·L S Dreifus, J Morganroth
Jan 1, 1978·The Journal of International Medical Research·K Charoenlarp, N Jaroonvesama
Jan 1, 1979·The American Journal of Cardiology·W S AronowS Van Camp
Jul 19, 1975·Lancet·C R KumanaJ Hamer
Feb 1, 1986·International Journal of Cardiology·P A Crean, D O Williams
May 1, 1977·Circulation·A H GradmanD C Harrison
Nov 1, 1981·British Journal of Clinical Pharmacology·M J LewisA H Henderson
Mar 1, 1985·Journal of Clinical Pharmacology·E V PlatiaP R Reid
Aug 1, 1982·British Journal of Clinical Pharmacology·C Y Hong, P Turner
Jun 1, 1979·The Journal of Pharmacy and Pharmacology·D Attwood, S P Agarwal
Feb 1, 1975·British Journal of Clinical Pharmacology·M F Cuthbert, R F Collins
Sep 1, 1983·British Journal of Clinical Pharmacology·R S SmithC F George

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.