Beta-adrenoceptor-stimulated renin release is blunted in old rats.

Journal of the American Society of Nephrology : JASN
C BaylisW H Beierwaltes

Abstract

Plasma renin activity (PRA) was similar in young versus old male Sprague Dawley rats under unstressed conditions (1.3 +/- 0.2 versus 1.8 +/- 0.3 ng angiotensin I/ml per min). Airjet stress increases PRA in young but not old rats (13.9 +/- 3.8 versus 2.9 +/- 0.8 ng angiotensin I/ml per min), respectively. This response is ablated in young rats by beta-adrenoceptor blockade, suggesting that the increased PRA is mediated by beta-adrenoceptors, and this response was blunted in old rats.

Citations

Feb 11, 2005·American Journal of Physiology. Renal Physiology·Roland VeelkenRoland E Schmieder
Sep 1, 2005·International Urology and Nephrology·Fred G Silva
Jan 4, 2007·The Journal of Pathology·J E Martin, M T Sheaff
May 8, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert L ThunhorstAlan Kim Johnson
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathleen S Curtis
Aug 27, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert L ThunhorstAlan Kim Johnson
Feb 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert L ThunhorstAlan Kim Johnson

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