PMID: 8594552Oct 1, 1995Paper

beta-Adrenoceptor stimulation activates large-conductance Ca2+-activated K+ channels in smooth muscle cells from basilar artery of guinea pig

Pflügers Archiv : European journal of physiology
Y Song, J M Simard

Abstract

We studied the effect of isoproterenol on the Ca2+-activated K+ (BK) channel in smooth muscle cells isolated from the basilar artery of the guinea pig. Cells were studied in a whole-cell configuration to allow the clamping of intracellular Ca2+ concentration, [Ca2+]i. Macroscopic BK channel currents were recorded during depolarizing test pulses from a holding potential (VH) of 0 mV, which was used to inactivate the outward rectifier. The outward macroscopic current available from a VH of 0 mV was highly sensitive to block by external tetraethylammonium Cl (TEA) and charybdotoxin, and was greatly augmented by increasing [Ca2+]i from 0.01 to 1.0 microM. With [Ca2+]i between 0.1 and 1.0 microM, 0.4 microM isoproterenol increased this current by 58.6 +/- 17.1%, whereas with [Ca2+]i at 0.01 microM a sixfold smaller increase was observed. With [Ca2+]i > or = 0.1 microM, 100 microM dibutyryl -adenosine 3':5: cyclic monophosphate (cAMP) and 1 microM forskolin increased this current by 58.5 +/- 24.1% and 59.7 +/- 10.3%, respectively. The increase with isoproterenol was blocked by 4.0 microM propranolol extracellularly, and by 10 U/ml protein kinase inhibitor intracellularly. Single-channel openings during depolarizing test pulses from a...Continue Reading

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