Beta adrenoceptors of human red blood cells, determination of their subtypes
F BreeJ P Tillement
The characteristics of beta adrenergic receptors of human erythrocyte membranes were investigated using (-)125iodocyanopindolol as a radioligand. Inhibition of (-)125iodocyanopindolol specific binding was checked using either atenolol and metoprolol as beta 1 selective antagonists or ICI 118551 and IPS 339 as beta 2 selective antagonists. The results showed non linear Hofstee's plots suggesting that both beta 1 and beta 2 adrenergic receptors are present. Analysis of the data yielded a beta 1/beta 2 adrenergic receptor ratio of approximately 33/67. Thus it is concluded that beta 2 subtype is predominant on human erythrocyte membranes.
Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.