PMID: 39711Jan 1, 1978

beta-Adrenoreceptors of the posterior hypothalamus

Clinical and Experimental Hypertension : CHE
A Philippu, U Stroehl

Abstract

Cats were anaesthetized with pentobarbital sodium. A push-pull cannula was inserted into the posterior hypothalamus which was superfused through the cannula and electrically stimulated with its tip. Electrical stimulation elicited a frequency-dependent pressor response and tachycardia. Superfusion with orciprenaline, isoprenaline (beta 1- and beta 2-stimulants) or tazolol (beta 1-stimulant) led to a concentration-dependent enhancement in the pressor response. Superfusion with terbutaline caused a slight and late increase in the pressor response, while salbutamol (beta 2-stimulants) was ineffective. The tachycardia elicited by the hypothalamic stimulation was slightly increased by the hypothalamic stimulation was slightly increased by orciprenaline, tazolol and terbutaline. Superfusion with atenolol (beta 1-adrenoreceptor blocking drug) or butoxamine (beta 2-adrenoreceptor blocking drug) inhibited the pressor response and the tachycardia caused by hypothalamic stimulation. Superfusion with butoxamine prior to isoprenaline reduced the enhancing effect of isoprenaline on the pressor response, while superfusion with atenolol abolished or even reversed it. It is concluded that beta 1 and beta 2-adrenoreceptors are present in the pos...Continue Reading

References

Apr 26, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·A Philippu, E Kittel
Jul 26, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A PhilippuH Przuntek
Mar 9, 1965·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·D WINNE

Citations

Jul 1, 1983·The International Journal of Neuroscience·J S Richardson, E K Chiu
Nov 1, 1985·British Journal of Pharmacology·G A Bentley, I W Copeland

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Sultanol
Tenormin
Diastolic Blood Pressure
Butoxamine Hydrochloride
Felis catus
Electric Stimulation Technique
Organum Vasculosum Laminae Terminalis
Posterior Hypothalamic Region

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