Abstract
Asthma mortality surveys report delays in seeking medical review and overuse of beta-agonist therapy as factors contributing to a fatal outcome. However, the strength of these associations is limited because many asthma deaths are unwitnessed. We undertook a secondary analysis of data from a 24-week randomised controlled trial of 303 patients with high-risk asthma, randomised to combination budesonide/formoterol inhaler according to a single maintenance and reliever therapy regimen or fixed dose budesonide/formoterol with salbutamol as reliever (Standard) regimen. Medication use was measured by electronic monitors. The thresholds for high, marked and extreme beta-agonist use days were defined in the single maintenance and reliever therapy arm as: >8, >12 and >16 actuations of budesonide/formoterol in excess of four maintenance doses, respectively; and in the Standard arm as: >16, >24 and >32 actuations of salbutamol, respectively. Whether a medical review was obtained within 48 h of an overuse episode was determined by review of data collected during the study by participant report. The mean (standard deviation) proportion of days in which high, marked and extreme beta-agonist overuse occurred without medical review within 48 h...Continue Reading
References
Feb 20, 1992·The New England Journal of Medicine·W O SpitzerA S Rebuck
Dec 1, 1992·The American Review of Respiratory Disease·C S RandD P Tashkin
Oct 1, 1991·Australian and New Zealand Journal of Medicine·R BeasleyC Burgess
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·M R Sears, R Beaglehole
Sep 1, 1994·The European Respiratory Journal·S SuissaP Ernst
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·S SuissaW O Spitzer
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·H MilgromC Rand
Dec 25, 2004·BMJ : British Medical Journal·H Ross AndersonChristina R Victor
Jul 13, 2005·Pulmonary Pharmacology & Therapeutics·V M BalanagC Jorup
Feb 4, 2006·The European Respiratory Journal·A R RubinfeldO Selroos
May 17, 2006·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Shaun HoltRichard Beasley
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Mar 31, 2010·The European Respiratory Journal·F de VriesT P van Staa
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Cynthia S RandVirginia Taggart
Aug 28, 2012·The Journal of Allergy and Clinical Immunology·Mitesh PatelRichard Beasley
Jan 30, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mitesh PatelRichard Beasley
Nov 16, 2013·The Journal of Allergy and Clinical Immunology. in Practice·Mitesh PatelRichard Beasley
Dec 11, 2013·The Lancet. Respiratory Medicine·Mitesh PatelUNKNOWN SMART Study Group
Jan 9, 2015·NPJ Primary Care Respiratory Medicine·Mitesh PatelUNKNOWN SMART Study Group
Aug 26, 2015·Breathe·Mark L Levy
Citations
Feb 4, 2019·Current Allergy and Asthma Reports·Steve Kagen, Amy Garland
Aug 26, 2020·Thorax·Matthew J MartinTim W Harrison
Jul 29, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Olivier ZhangSherif Gonem
May 24, 2020·The European Respiratory Journal·Christina BaggottUNKNOWN PRACTICAL Study Team
Nov 7, 2020·Scientific Reports·Ronit HadadTzahit Simon-Tuval
May 25, 2021·Atencion primaria·Miguel Román RodríguezMario Bárcena Caamaño