PMID: 8581496Nov 6, 1995Paper

Beta-amyloid (1-42) affects cholinergic but not parvalbumin-containing neurons in the septal complex of the rat

Brain Research
T HarkanyK Gulya

Abstract

beta-Amyloid(1-42) peptide (beta AP(1-42) was injected into the medial septum of rats. After a 14-day survival time, neuronal alterations in the septal cholinergic and GABAergic systems were visualized by means of histo- and immunocytochemical methods. Neurons insulted by the peptide were primary choline acetyltransferase-immunoreactive (ir), while only minor effects of beta AP(1-42) were observed on parvalbumin-ir interneurons. These results indicate that the changes in intracellular Ca2+ level elicited by beta AP(1-42) may contribute to beta-amyloid neurotoxicity, and Ca(2+)-binding proteins may play an important role in the protection against the neurotoxic effects of beta AP(1-42).

Citations

Jan 15, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michel J GrotheUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 12, 2015·The Journal of Biological Chemistry·Masanori ItakuraTadayoshi Takeuchi
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·T A Good, R M Murphy
Jan 13, 2006·Journal of Neurochemistry·Luis V Colom
Nov 1, 2018·Journal of Molecular Neuroscience : MN·Pritha GuptaTusharkanti Ghosh
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Jan 6, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T HarkanyC Nyakas
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