PMID: 9185683May 23, 1997Paper

beta-Amyloid (A beta) deposition in the medial temporal lobe of patients with dementia with Lewy bodies

Neuroscience Letters
R A ArmstrongP L Lantos

Abstract

The distribution and density of diffuse, primitive and classic beta-amyloid (A beta) deposits in the medial temporal lobe (MTL) was studied in cases of dementia with Lewy bodies (DLB) with and without associated Alzheimer's disease (AD) and 15 cases of sporadic AD. In the 'pure' DLB cases, virtually no A beta deposits were observed in the CA regions of the hippocampus or dentate gyrus whereas deposits were distributed throughout the MTL in DLB/AD and AD cases. Densities of diffuse and primitive A beta deposits were similar in AD and DLB/AD cases but density was significantly reduced in the 'pure' DLB cases. The density of the classic deposits was significantly reduced in DLB cases with or without associated AD compared with AD cases. These results suggest that A beta deposition in the MTL in 'pure' DLB cases is similar to that of elderly non-demented patients while, with the exception of the classic deposits, A beta deposition in DLB/AD cases is similar to that in cases of AD alone.

References

Nov 1, 1992·Neurology·E WuD W Dickson
Apr 10, 1992·Science·J A Hardy, G A Higgins
Feb 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·W R GibbP L Lantos
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Mar 1, 1996·Journal of the Neurological Sciences·C KawanishiT Yamamoto

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Citations

Aug 26, 1998·Neuropathology and Applied Neurobiology·A J Harding, G M Halliday
Dec 4, 2012·Alzheimer Disease and Associated Disorders·Michael GrundmanUNKNOWN 45-A17 Study Group
May 7, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Richard A ArmstrongNigel J Cairns
Jun 28, 2012·Journal of Neurochemistry·Kenjiro OnoMasahito Yamada
Feb 15, 2002·Brain : a Journal of Neurology·A J HardingG M Halliday
Jul 28, 2006·American Journal of Alzheimer's Disease and Other Dementias·Richard A Armstrong
Apr 18, 1998·Brain Pathology·P G InceC M Morris
Feb 24, 2001·Annals of the New York Academy of Sciences·E Gómez-TortosaB T Hyman
Nov 11, 1998·Journal of the American Geriatrics Society·E Gómez-TortosaB T Hyman
Dec 1, 2020·Biophysical Chemistry·Magdalena I IvanovaAyyalusamy Ramamoorthy
Sep 11, 2021·Molecular Neurodegeneration·Grace M LloydDavid R Borchelt

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