PMID: 9535128Apr 16, 1998Paper

Beta-amyloid peptide 25-35 regulates basal and hormone-stimulated Ca2+ levels in cultured rat astrocytes

Neuroscience Letters
B Stix, G Reiser

Abstract

Beta-amyloid peptide (beta-AP), a characteristic constituent found in senile plaques characteristic for Alzheimer's disease, is neurotoxic by a still largely unknown mechanism. The fragment beta-AP 25-35 induces the full neurotoxic effects. It is important to understand for neurons and astrocytes the influence of beta-AP on Ca2+, a key regulator in cell toxicity and cell damage. Here we examined the effects of acute application of beta-A4 and beta-AP 25-35 on the regulation of cytosolic Ca2+ ([Ca2+]i) in rat astrocytes in primary culture. Transient [Ca2+]i rise in astrocytes induced by a brief stimulation with beta-AP was most probably due to release of Ca2+ from intracellular stores which was exacerbated by reduced extracellular Ca2+ indicating the involvement of receptors sensing extracellular Ca2+. Furthermore, P2 receptor-induced [Ca2+]i oscillations in astrocytes were reversibly interrupted by beta-AP.

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Citations

Jun 18, 2004·Cell Calcium·Gerda E BreitwieserMingliang Zhang
Jan 28, 2004·Free Radical Biology & Medicine·Haiyan ZengBaolu Zhao
Feb 20, 2003·Neurochemistry International·András PalotásBotond Penke
Jan 6, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T HarkanyC Nyakas
Jul 22, 2005·Journal of Neurochemistry·Tursonjan TokayMarie-Christine Tonon
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Apr 30, 2009·Brain Research·Christopher S CasleyAnn E Kingston
Aug 8, 2006·Biochemical and Biophysical Research Communications·Yan-Hua LinXue-Jun Li
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Nov 3, 2016·F1000Research·Matilde ColellaSilvana Curci
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Jan 26, 2005·Biochemical Society Transactions·D Riccardi, D Maldonado-Perez
Nov 9, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hyeon-Jin KimSeong-Tshool Hong
Mar 29, 2006·Journal of Biochemistry·Jayaraman Murali, Rajadas Jayakumar
May 22, 2019·Cold Spring Harbor Perspectives in Biology·Alexei Verkhratsky

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