Beta and gamma human papillomaviruses in anal and genital sites among men: prevalence and determinants.

Scientific Reports
Vitaly SmelovTarik Gheit

Abstract

Data regarding the anogenital distribution of and type-specific concordance for cutaneous β- and γ-HPV types in men who have sex with women is limited and geographically narrow. Knowledge of determinants of anogenital detection of cutaneous HPV types in different regions is needed for better understanding of the natural history and transmission dynamics of HPV, and its potential role in the development of anogenital diseases. Genital and anal canal samples obtained from 554 Russian men were screened for 43 β-HPVs and 29 γ-HPVs, using a multiplex PCR combined with Luminex technology. Both β- and γ-HPVs were more prevalent in the anal (22.8% and 14.1%) samples than in the genital (16.8% and 12.3%) samples. Low overall and type-specific concordance for β-HPVs (3.5% and 1.1%) and γ-HPVs (1.3% and 0.6%) were observed between genital and anal samples. HIV-positive men had higher anal β- (crude OR = 12.2, 95% CI: 5.3-28.1) and γ-HPV (crude OR = 7.2, 95% CI: 3.3-15.4) prevalence than HIV-negative men. Due to the lack of genital samples from the HIV-positive men, no comparison was possible for HIV status in genital samples. The lack of type-specific positive concordance between genital and anal sites for cutaneous β- and γ-HPV types in ...Continue Reading

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Citations

Nov 6, 2018·The Journal of Infectious Diseases·Rachel L WinerMassimo Tommasino
May 28, 2019·Frontiers in Oncology·Tarik Gheit
Apr 9, 2020·BMC Infectious Diseases·Elisa M BolattiAdriana A Giri
Dec 1, 2020·The Journal of Infection·Luisa GalatiTarik Gheit
Jun 15, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ilia BeliakovAlexander Guschin
Jan 24, 2019·Acta Cytologica·Laura SicheroMassimo Tommasino

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Stata

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