Beta and gamma range EEG power-spectrum correlation with spiking discharges in DBA/2J mice absence model: role of GABA receptors

Epilepsia
Francesco MarrosuGiampaolo Mereu

Abstract

To describe the correlations between spiking pattern and EEG power spectrum frequency in DBA/2J mice, a model for murine absence seizures, after gamma-aminobutyric acid (GABA)(B) modulation. The animals were first tested with the GABA(B) agonist l-baclofen followed by the GABA(B) antagonist SCH 50911. Moreover, digital EEGs recorded under experimental conditions were processed at baseline and 10 and 20 min after l-baclofen injection. This procedure was followed by injection of the GABA(B) antagonist SCH50911 and by an additional EEG evaluation at 10 and 20 min from drug administration. The power spectra analysis of signals was obtained for delta (0.5-3 Hz), theta (3.5-7.5 Hz), alpha (8-12 Hz), beta (13-20 Hz), and gamma (21-50 Hz) frequencies. The spiking pattern and power spectrum of beta activity was increased by <or=80% after administration of 5 mg/kg l-baclofen, whereas gamma power frequency decreased to the same extent. After administration of 50 mg/kg SCH 50911, spiking activity and beta power frequencies were markedly reduced (>80%), whereas gamma power increased (correlation, 0.92; p < 0.001). The remaining frequency bands were unaffected. This study confirms the potential of GABA(B) antagonists in contrasting seizure a...Continue Reading

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Citations

Jul 3, 2007·Psychopharmacology·Marco BortolatoFrancesco Marrosu
Nov 28, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Faranak FarzanZafiris J Daskalakis
Apr 19, 2008·Journal of Neuroscience Methods·Chiping WuLiang Zhang
Jul 13, 2007·Epilepsy Research·Francesco MarrosuGiampaolo Mereu
May 28, 2014·Genes, Brain, and Behavior·V A LettsW N Frankel
Mar 18, 2010·Seizure : the Journal of the British Epilepsy Association·Marco BortolatoFrancesco Marrosu
Dec 20, 2014·Brain : a Journal of Neurology·Natasha RadhuZafiris J Daskalakis
Oct 28, 2016·Brain Research Bulletin·Mostafa JalilifarZohreh Ghotbeddin
Mar 30, 2012·Journal of Neurophysiology·Florinda FerreriSara Määttä
Mar 23, 2018·Acta Pharmacologica Sinica·Meng-Yi Xu, Albert H C Wong

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