PMID: 6106149Sep 1, 1980Paper

Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics

Metabolism: Clinical and Experimental
G C VibertiS R Bloom

Abstract

The effect of the administration of a single oral dose of placebo, oxprenolol and metoprolol on insulin-induced hypoglycemia was investigated in seven insulin-dependent diabetics in a double-blind randomized study. Neither of the beta-blocking agents accelerated the plasma glucose lowering effect of insulin. Plasma glucose recovery from hypoglycemia was grossly impaired in diabetics whether blocked or not, and all investigations had to be terminated by i.v. glucose injection after 1 hr of sustained hypoglycemia. During the period of observation, no further delaying effect by either beta-blocker was observed. The lack of plasma glucose recovery seems to be at least in part related to a retarded and reduced glucagon response to hypoglycemia. Both drugs blocked the hypoglycemia-induced pulse rate increase, but neither caused bradycardia. A significant increase in diastolic pressure was recorded with oxprenolol, whereas a drop in systolic pressure was noted with metoprolol. Oxprenolol suppressed the NEFA rise after insulin-infusion termination to a greater extent than did metoprolol. Hypoglycemic symptoms were not affected by beta-blockade. The results suggest that neither drug further worsens the already grossly impaired plasma gl...Continue Reading

References

Apr 1, 1979·Diabetologia·N J Christensen
Jun 1, 1976·British Journal of Clinical Pharmacology·M J WestE B Faragher
Jul 1, 1970·Metabolism: Clinical and Experimental·W G Blackard, G J Hubbell

❮ Previous
Next ❯

Citations

Sep 22, 1995·Pharmacy World & Science : PWS·L BergendalA Schaffrath
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Jul 17, 2001·Journal of Internal Medicine·P T Sawicki, A Siebenhofer
Oct 28, 1982·The New England Journal of Medicine·K PolonskyA Rubenstein
Jul 20, 1983·The American Journal of Cardiology·W J LouisO H Drummer
Mar 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·W Y Tse, M Kendall
Jul 1, 1985·Postgraduate Medical Journal·A D Struthers
May 1, 1982·Acta Medica Scandinavica·K KølendorfB Broch-Møller
May 1, 1993·Metabolism: Clinical and Experimental·U M Kabadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.