Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation

Clinical Pharmacology and Therapeutics
Sandrine KubliBernard Waeber

Abstract

Nebivolol is a selective beta(1)-adrenoceptor blocker that has a vasorelaxant activity thought to be the result of a facilitation of the release of nitric oxide from the endothelium. This study was undertaken in 12 healthy male volunteers to assess whether this compound increases the vasodilatory response to acetylcholine when administered orally at a dose commonly recommended for the treatment of cardiovascular diseases. The subjects were randomly allocated to an 8-day treatment with nebivolol (5 mg once a day) and atenolol (50 mg once a day) according to a cross-over design. The two treatments were separated by a 1-week washout period. On the first and the last day of each treatment phase, both before drug administration and 3 hours after drug administration, the forearm skin blood flow response to acetylcholine applied by iontophoresis was determined with the use of a laser Doppler scanner imaging system. The reactivity to acetylcholine was significantly increased 3 hours after the administration of nebivolol on both the first and the last day of treatment, whereas atenolol had no effect on this parameter. These data therefore indicate that nebivolol, but not atenolol, enhances the vasorelaxant activity of acetylcholine in t...Continue Reading

Citations

Aug 3, 2005·Journal of Human Hypertension·C Thuillez, V Richard
Feb 13, 2003·British Journal of Clinical Pharmacology·Melinda M ParnellDavid M Kaye
Nov 11, 2006·British Journal of Clinical Pharmacology·Jean LefebvreYves Lacourciere
Jan 8, 2004·The Journal of Investigative Dermatology·Yann BoegliFrançois Feihl
Oct 1, 2008·Current Therapeutic Research, Clinical and Experimental·Kaan GiderogluGuler Bugdayci
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·John LekakisCharalambos Vlachopoulos
Jan 20, 2011·Bulletin of Experimental Biology and Medicine·V M Chertok, A E Kotsyuba
Dec 18, 2007·Journal of Clinical Pharmacology·L Michael Prisant
Dec 25, 2016·Pharmacological Reviews·Italo Biaggioni
Aug 27, 2002·Journal of Hypertension·Luc Van Bortel
Oct 28, 2016·Drugs·Alan C CameronRhian M Touyz
Jan 5, 2002·Journal of Clinical Laser Medicine & Surgery
Dec 4, 2003·Pharmacology & Therapeutics·Noboru Toda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

The British Journal of Oral & Maxillofacial Surgery
T Hata, M Hosoda
American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
J E Pessa
© 2021 Meta ULC. All rights reserved