Beta blocker use and colorectal cancer risk: population-based case-control study

Cancer
Lina JansenMichael Hoffmeister

Abstract

Recently, it has been postulated that long-term use of beta blockers might decrease the risk of certain types of cancer because of weakening of norepinephrine signaling. Previous studies on colorectal cancer (CRC) yielded inconsistent results, but lacked information on covariates. Thus, the authors investigated the association of beta blocker use and CRC risk in a large population-based case-control study (DACHS study). Between 2003 and 2007, information on beta blocker use and potential confounders was collected by personal interviews for 1762 CRC cases and 1708 control individuals from Germany. The association of CRC risk and beta blocker use and subclasses of beta blockers was estimated by multiple logistic regression. In addition, site- and stage-specific analyses were performed. After adjustment for covariates, no association was observed with beta blocker use (odds ratio [OR], 1.05; 95% confidence interval [CI], 0.86-1.29) or with duration of beta blocker use. Also, the analysis by subclasses of beta blockers (cardioselectivity) and active ingredients (metoprolol, bisoprolol, carvedilol, and atenolol) or by CRC subsite showed no associations. In stage-specific analyses, long-term beta blocker use (6+ years) was associated...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Jan 1, 1989·Journal of Clinical Epidemiology·W D FlandersJ R Boring
Nov 1, 1986·British Medical Journal·J Coope, T S Warrender
Jan 1, 1986·Journal of Chronic Diseases·A R FeinsteinR I Horwitz
Jul 1, 1996·American Journal of Hypertension·M PahorR J Havlik
Aug 12, 1998·Statistics in Medicine·F Y HsiehM D Larsen
Apr 18, 2002·The American Journal of Medicine·Ehud GrossmanUri Goldbourt
Apr 27, 2004·Revue D'épidémiologie Et De Santé Publique·M AlgaziM G Lê
Jul 29, 2004·Cancer Causes & Control : CCC·Linda PerronFrançois Meyer
Sep 28, 2007·Current Pharmaceutical Design·Patrick K Y GoonGregory Y H Lip
Jan 5, 2008·American Journal of Hypertension·Ruben O HalperinHoward D Sesso
Sep 10, 2008·Pharmacoepidemiology and Drug Safety·Themistocles L AssimesSamy Suissa
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Paul J Fitzgerald
Jan 15, 2009·International Journal of Cancer. Journal International Du Cancer·Peter S LiangEdward Giovannucci
Feb 12, 2009·British Journal of Cancer·K Y WolinI-M Lee
Jun 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y NingE L Giovannucci
Oct 16, 2009·Journal of Hypertension·Au Bich ThuyTerence Dwyer
Mar 25, 2010·International Journal of Cancer. Journal International Du Cancer·Gary D FriedmanLaurel A Habel
Jun 8, 2010·Cancer Causes & Control : CCC·Joan A LargentHoda Anton-Culver
Jan 5, 2011·Annals of Internal Medicine·Hermann BrennerMichael Hoffmeister
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amal Melhem-BertrandtAna-Maria Gonzalez-Angulo
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas I BarronKala Visvanathan

❮ Previous
Next ❯

Citations

Aug 6, 2013·Breast Cancer Research and Treatment·Edoardo BotteriSara Gandini
Jul 19, 2012·Clinical Epidemiology·Paul J Fitzgerald
Dec 12, 2012·OncoTargets and Therapy·Yi JiKai Li
Dec 20, 2012·Expert Review of Anticancer Therapy·Vincenzo De GiorgiPierangelo Geppetti
Feb 2, 2013·Current Medical Research and Opinion·Matteo MonamiEdoardo Mannucci
Feb 24, 2015·International Journal of Cardiology·Chin-Sheng LinChia-Hung Kao
Nov 5, 2013·Mayo Clinic Proceedings·Manish Kohli
Sep 12, 2015·Journal of Digestive Diseases·Yoshitaka WatanabeKazuhiko Koike
Jun 21, 2013·International Journal of Cancer. Journal International Du Cancer·Alberto MilanFranco Veglio
Apr 8, 2016·Journal of Anesthesia·Kazuyoshi Hirota
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Shahid Akbar, Mansour Saleh Alsharidah
Jul 15, 2015·Medicine·Ping-Ying ChangChia-Hung Kao
May 21, 2015·Journal of Pharmaceutical Policy and Practice·Rawan SaadehAkihiro Seita
Mar 15, 2015·Journal of the National Cancer Institute·Michael HoffmeisterHermann Brenner
Sep 19, 2019·Oncogene·Shu-Heng JiangZhi-Gang Zhang
Dec 10, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Beade NumbereTimothy R Card
Mar 11, 2020·Cardio-Oncology·Neha BansalSteven E Lipshultz
Nov 22, 2012·Experimental and Therapeutic Medicine·Jessica StilesBrad A Bryan
May 17, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joel N SwerdelJohn B Kostis
Jun 13, 2020·American Journal of Hypertension·Elias SanidasJohn Barbetseas
Jul 10, 2021·PloS One·Jihye ParkDong Ho Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Gary D FriedmanLaurel A Habel
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Steven W Cole, Anil K Sood
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Stanley LemeshowRonald Glaser
© 2021 Meta ULC. All rights reserved