Beta-blockers for congestive heart failure in children

The Cochrane Database of Systematic Reviews
Samer AlabedAnne-Kristina Frobel-Mercier

Abstract

Beta-blockers are an essential part of standard therapy in adult congestive heart failure and therefore, are expected to be beneficial in children. However, congestive heart failure in children differs from that in adults in terms of characteristics, aetiology, and drug clearance. Therefore, paediatric needs must be specifically investigated. This is an update of a Cochrane review previously published in 2009. To assess the effect of beta-adrenoceptor-blockers (beta-blockers) in children with congestive heart failure. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and LILACS up to November 2015. Bibliographies of identified studies were checked. No language restrictions were applied. Randomised, controlled, clinical trials investigating the effect of beta-blocker therapy on paediatric congestive heart failure. Two review authors independently extracted and assessed data from the included trials. We identified four new studies for the review update; the review now includes seven studies with 420 participants. Four small studies with 20 to 30 children each, and two larger studies of 80 children each, showed an improvement of congestive heart failure with beta-blo...Continue Reading

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Citations

Aug 7, 2018·Cardiology in the Young·Hirofumi WatanabeMamoru Ayusawa
Nov 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nida Siddiqi, Ibrahim F Shatat

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