Beta-blockers have a beneficial effect upon endothelial function and microalbuminuria in African-American subjects with diabetes and hypertension.

Journal of Diabetes and Its Complications
Ali JawaVivian Fonseca

Abstract

Type 2 diabetes mellitus (T2DM) with microalbuminuria (MA) is associated with increased risk of cardiovascular events (CVE) that may be attenuated by angiotensin-converting enzyme inhibitors (ACEIs), unless microalbuminuria persists (PMA). African-Americans (AA) have a higher prevalence of nephropathy with suboptimal response to ACEIs. We studied the effects of beta-blockers addition and comparative effects of carvedilol with metoprolol on 24-h urinary-albumin excretion (UAE) and endothelial function (EF) in AA with PMA. Thirty-four AA 30-70 years of age with T2DM and PMA despite ACEI therapy were randomized to receive carvedilol or metoprolol in addition to ACEI and any other concurrent therapy. Carvedilol/metoprolol dose was titrated to achieve blood pressure (BP) <130/80 mm Hg. UAE and brachial-artery reactivity were studied at baseline and 12 weeks. We analyzed the effects of addition of beta-blockers and whether there was any difference in response between the two beta-blockers. Thirty-three subjects completed the study; BP decreased to <135/80 mm Hg. After 12 weeks, beta-blocker treatment resulted in significant increase in flow-mediated dilatation (FMD) from 3.5+/-1% to 8.5+/-1% (P=.004) and significant reduction in mean...Continue Reading

References

Oct 1, 1996·Journal of Clinical Pharmacology·L M Prisant, G A Mensah
May 1, 1997·Journal of Human Hypertension·V N PavlikK Louis
May 1, 1999·Clinical Pharmacology and Therapeutics·D S JonesD R Abernethy
Jun 1, 2000·Southern Medical Journal·K C Ferdinand
Nov 21, 2002·JAMA : the Journal of the American Medical Association·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Apr 30, 2003·Hypertension·Lorenzo GhiadoniAntonio Salvetti
Nov 10, 2004·The New England Journal of Medicine·Anne L TaylorUNKNOWN African-American Heart Failure Trial Investigators
Nov 10, 2004·The New England Journal of Medicine·M Gregg Bloche
Nov 13, 2004·JAMA : the Journal of the American Medical Association·George L BakrisUNKNOWN GEMINI Investigators

❮ Previous
Next ❯

Citations

Apr 18, 2014·Indian Journal of Pharmacology·Maggie M RamzyMohamed A Morsy
Jul 6, 2014·BioMed Research International·Mohamed A MorsyMagdy K Hassan
Nov 11, 2009·Expert Review of Cardiovascular Therapy·Gianpaolo ReboldiPaolo Verdecchia
Jan 16, 2010·Expert Opinion on Drug Metabolism & Toxicology·Subhashis ChakrabortySanjay Singh
Sep 22, 2009·Clinics in Geriatric Medicine·Maria Czarina Acelajado, Suzanne Oparil
Jan 27, 2012·The Journal of Clinical Hypertension·Aaron S KellyAlan J Bank
Jul 24, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Xiucai JinXiaoyu Chen
Jun 27, 2017·Journal of Hypertension·Lawrence H KwonClive Rosendorff
Mar 10, 2009·Diabetes/metabolism Research and Reviews
May 7, 2009·Current Opinion in Cardiology·Michala E Pedersen, John R Cockcroft
Dec 11, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiaotong WangNanfang Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.