PMID: 6110954Apr 4, 1981Paper

beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects

G Berglund, O Andersson


The antihypertensive effect and metabolic side effects of bendroflumethiazide have been compared with those of propranolol in two randomly selected groups, of 53 previously untreated middle-aged men during 6 years' treatment for mild to moderately severe essential hypertension. The blood pressure-reduction was the same in the two groups. During the follow-up 1 man in the bendroflumethiazide group and 3 in the propranolol group died while 2, 1 on each treatment, became diabetic. None had gout but serum urate increased in both groups. Glucose tolerance improved significantly in both groups during the first year and this improvement was sustained for the follow-up period. Serum potassium did not differ in the two groups during the first 5 years but during the sixth year it decreased in the diuretic group. Total potassium was, however, unchanged in both groups. These results indicate that the frequency of metabolic side effects during diuretic treatment of mild to moderately severe essential hypertension is low and has been grossly exaggerated. Since the antihypertensive effect and side effects were equal with both drugs, and since the diuretics are cheaper, they should be the drug of first choice in this type of hypertension.


Mar 1, 1990·Journal of Clinical Pharmacology·Y A Ding, S M Shieh
Jan 1, 1983·European Journal of Clinical Pharmacology·S Rössner, L Weiner
Jan 1, 1983·European Journal of Clinical Pharmacology·L A FerraraF Galletti
Jan 1, 1985·European Journal of Clinical Pharmacology·K HarnoM Verho
Jan 1, 1987·European Journal of Clinical Pharmacology·G Olsson, N Rehnqvist
Jan 1, 1989·European Journal of Clinical Pharmacology·G Frithz
Nov 1, 1987·Journal of General Internal Medicine·W Engel, J Sawyer
Apr 1, 1991·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·J S Turkkan, M K Story
Jan 1, 1992·Pharmacology & Therapeutics·G D Johnston
Oct 1, 1992·Baillière's Clinical Endocrinology and Metabolism·R E Ferner
May 1, 1990·The Journal of School Health·S M DesmondP W Stewart
Jun 25, 1983·British Medical Journal·J P Thomas, W H Thomson
Jun 1, 1983·Journal of Epidemiology and Community Health·E ArnesenO D Mjøs
Oct 5, 1984·The American Journal of Medicine·R W Gifford
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·N M Kaplan
Sep 25, 2014·Annual Review of Pharmacology and Toxicology·R D FeldmanS W Tobe
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·T HednerG Berglund
Jul 1, 1984·Clinics in Endocrinology and Metabolism·P A Poole-Wilson
Apr 22, 1991·The American Journal of Cardiology·P FerrariP Weidmann
Sep 18, 1987·The American Journal of Cardiology·N E Miller
Apr 19, 2018·The Cochrane Database of Systematic Reviews·James M WrightRupam Gill
Aug 17, 2017·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Mar 11, 2016·The Cochrane Database of Systematic Reviews·Garry TavernyFrancois Gueyffier
Jul 10, 2009·The Cochrane Database of Systematic Reviews·James M Wright, Vijaya M Musini
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S JohanssonC Wilhelmsson
Sep 1, 1988·Hypertension·M Moser
Sep 1, 1983·Hypertension·P WeidmannR Mordasini
Jun 6, 2019·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Mar 5, 2003·Pharmacological Reviews·Máire E Doyle, Josephine M Egan
Jan 21, 2017·The Cochrane Database of Systematic Reviews·Charles S WiysongeLionel H Opie
Sep 1, 1988·Journal of Clinical Pathology·A M McBainI W Campbell
Dec 1, 1983·British Journal of Clinical Pharmacology·A MarkelM B Youdim
Jan 1, 1988·Acta Medica Scandinavica·H ErikssonL Wilhelmsen
Jul 1, 1985·Pharmacotherapy·N M Kaplan

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