PMID: 1749Jan 1, 1976

beta-Bungarotoxin, a pre-synaptic toxin with enzymatic activity

Proceedings of the National Academy of Sciences of the United States of America
P N StrongR B Kelly

Abstract

beta-Bungarotoxin, a pre-synaptic neurotoxin isolated from the venom of the snake Bungarus multicinctus, has been shown to modify release of neurotransmitter at the neuromuscular junction. In this communication, we demonstrate that beta-bungarotoxin is a potent phospholipase A2 (phosphatide 2-acyl hydrolase, EC 3.1.1.4), comparable in activity with purified phospholipase enzymes from Naja naja and Vipera russellii. The phospholipase activity of beta-bungarotoxin requires calcium and is stimulated by deoxycholate. When strontium replaces calcium, no phospholipase activity is detected. Since neuromuscular transmission is not blocked when calcium is replaced by strontium, it was possible to examine the effects of the toxin on neuromuscular transmission in the presence of strontium. Under these conditions, when the phospholipase activity should be inhibited, the toxin has little or no effect on neuromuscular transmission. If beta-bungarotoxin owes its toxicity in part to its enzymatic activity, then it must be placed in a different class from those toxins which produce their effect by binding passively to an appropriate receptor.

References

Apr 22, 1975·Biochemistry·H L Kantor, J H Prestegard
Oct 1, 1975·Journal of Neurochemistry·J F WernickeB D Howard
Nov 5, 1971·Biochimica Et Biophysica Acta·J GoerkeP P Bonsen
Apr 5, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·C C Chang, M C Huang
May 1, 1974·Journal of Neurochemistry·J F WernickeB D Howard
May 20, 1974·Biochemical and Biophysical Research Communications·G M WagnerR B Kelly
Dec 1, 1972·The Journal of General Physiology·N KawaiH Grundfest
Oct 1, 1972·Toxicon : Official Journal of the International Society on Toxinology·F GranataN Frontali
Apr 16, 1973·Biochimica Et Biophysica Acta·S Batzri, E D Korn
Apr 1, 1974·Acta Physiologica Scandinavica·M A Kamenskaya, S Thesleff
Mar 26, 1974·Biochemistry·W A PietersonG H de Haas
Apr 24, 1968·Biochimica Et Biophysica Acta·G H de HaasL van DEENEN
Jun 1, 1972·Toxicon : Official Journal of the International Society on Toxinology·E KarlssonL Rydén
Jun 29, 1971·European Journal of Biochemistry·R A ShipoliniB E Banks
Aug 1, 1971·Archives of Biochemistry and Biophysics·J C Vidal, A O Stoppani
Aug 22, 1970·Nature·A R PooleJ A Lucy
Apr 22, 1970·Biochimica Et Biophysica Acta·J M Augustyn, W B Elliott
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Feb 12, 1963·Biochimica Et Biophysica Acta·L van DEENENC H HEEMSKERK

Citations

Feb 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D S HughesM Ontell
Feb 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D S Hughes, M Ontell
Jan 1, 1987·Cell and Tissue Research·C D McCaigA J Harris
Apr 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·M T Alderdice, R L Volle
Jan 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·C C Chang, J D Lee
Feb 15, 1977·Experientia·A E Zeller
Dec 20, 1978·Biochimica Et Biophysica Acta·G S TobiasW Shain
May 23, 1979·Biochimica Et Biophysica Acta·R A Hendon, A T Tu
Apr 1, 1990·Developmental Biology·K CondonW J Thompson
Nov 26, 1985·European Journal of Pharmacology·H C Huang, C Y Lee
Nov 13, 1990·European Journal of Pharmacology·J P Wang, C M Teng
Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·C C ChangJ Fohlman
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·E Habermann, H Breithaupt
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·B TchorbanovY Ovchinnikov
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·C J ChenC Y Lee
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·C C Chang, M J Su
Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·L G MagazanikU R Apsalon
Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·N Martin-Moutot, H Rochat
Jan 1, 1980·Toxicon : Official Journal of the International Society on Toxinology·C C Chang, M J Su
Jan 1, 1981·Toxicon : Official Journal of the International Society on Toxinology·J P DurkinW T Shier
Jan 1, 1981·Toxicon : Official Journal of the International Society on Toxinology·C C YangT P Sun
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·S Y Lin-Shiau, C C Chen
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·C Y LeeD P Botes
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·C Bon, B Saliou
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·J V Halliwell, J O Dolly
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·C L Ho, C Y Lee
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·W C ChangT B Lo
Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·M J Su, C C Chang
Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·H C Huang, C Y Lee
Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·C Ouyang, T F Huang
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·C K TseJ O Dolly
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J E Fletcher, J L Middlebrook
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·R M Kini, S Iwanaga
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·A GhassemiP Rosenberg
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·R M Kini, H J Evans
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·C M TengC Ouyang
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·P RosenbergC C Yang
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·J M Danse, J Kempf
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·C S LiuT B Lo
May 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·P B Usmanov, F A Nuritova
Jan 1, 1990·Pharmacology & Therapeutics·P N Strong
Jan 1, 1996·Neurochemistry International·M Israël, Y Dunant
Jun 30, 1982·Neuroscience Letters·J V Halliwell, J O Dolly
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·R M Kini
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·E G Rowan
Feb 27, 2001·Toxicon : Official Journal of the International Society on Toxinology·M BalassE Katchalski-Katzir
Jun 22, 2002·Toxicon : Official Journal of the International Society on Toxinology·S NirthananR Manjunatha Kini
Oct 9, 2002·Toxicon : Official Journal of the International Society on Toxinology·Yuan-Ping Chu, Long-Sen Chang
Apr 29, 1999·Toxicon : Official Journal of the International Society on Toxinology·C C Yang, H L Chan
May 9, 2001·Biochimica Et Biophysica Acta·R GaoP Gopalakrishnakone
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mariana Cintra-FrancischinelliCesare Montecucco
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·I SenJ R Cooper
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D R LivengoodW Shain
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T W JengH Fraenkel-Conrat
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R H Ng, B D Howard
Jun 15, 1982·European Journal of Biochemistry·G Marlas, C Bon
Dec 18, 1991·European Journal of Biochemistry·H Rehm
Jun 1, 1989·Journal of Protein Chemistry·H Rehm
Jun 6, 2009·Cellular and Molecular Life Sciences : CMLS·R Doley, R M Kini
Sep 5, 1977·Biochimica Et Biophysica Acta·P N Strong, R B Kelly
May 21, 1976·Biochimica Et Biophysica Acta·S G Oberg, R B Kelly
Jun 19, 1980·Biochimica Et Biophysica Acta·C OuyangC M Teng
May 15, 1978·Biochemical and Biophysical Research Communications·M R Hanley
May 1, 1979·Archives of Biochemistry and Biophysics·T J AndreasenM G McNamee
Feb 15, 1984·Archives of Biochemistry and Biophysics·P LazaroviciE Zlotkin
May 1, 1988·Analytical Biochemistry·N H Tan, C S Tan
Dec 15, 1982·Biochemical and Biophysical Research Communications·S P Noël, P N Strong
Jun 30, 1981·Toxicology and Applied Pharmacology·J E FletcherP Rosenberg
Jul 1, 1978·Archives of Biochemistry and Biophysics·T W Moody, M A Raftery
May 31, 1988·Biochemical and Biophysical Research Communications·H Rehm, M Lazdunski
Oct 18, 1976·Biochemical and Biophysical Research Communications·J R Gadag, R W Master
Nov 14, 1978·Biochemistry·R H Ng, B D Howard
Apr 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R Borja-OliveiraL Rodrigues-Simioni
Jul 30, 2014·Biochemical Pharmacology·Muhamad Rusdi Ahmad RusmiliIekhsan Othman
Mar 27, 2013·International Journal of Molecular Sciences·Sandra De KeijzerAlessandra Cambi
Feb 24, 1995·The Journal of Biological Chemistry·J M McIntoshB M Olivera
Nov 12, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T AbeR Miledi
Jun 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C G CaratschP N Strong
Jun 1, 1978·Journal of Neurochemistry·I Sen, J R Cooper
Jan 1, 1993·International Journal of Clinical & Laboratory Research·G VirellaM F Lopes-Virella
Dec 29, 2007·Critical Reviews in Toxicology·Sanjaya KuruppuWayne C Hodgson
Sep 28, 2019·Toxins·Tarek Mohamed Abd El-AzizJames D Stockand
Aug 9, 2020·Frontiers in Bioengineering and Biotechnology·Timothy Patrick Jenkins, Andreas Hougaard Laustsen
Oct 1, 1989·International Journal of Peptide and Protein Research·C S LiuT B Lo
Oct 1, 1986·Journal of Neurochemistry·D C Anderson, S M Parsons
May 1, 1985·The American Journal of Physiology·J I Stagner, E Samols

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