PMID: 11931610Apr 5, 2002Paper

Beta-C-mannosides as selectin inhibitors

Journal of Medicinal Chemistry
N KailaGiliyar Ullas

Abstract

Potential E- and P-selectin inhibitors were synthesized to explore a hydrophobic area on the E-selectin surface and the PSGL-1 protein binding site on the P-selectin surface that was recently defined by crystallography. Three series of mannose-based compounds (libraries A, B, and C) were synthesized using solution phase parallel synthesis. Biological evaluation of these compounds was done using two ELISA-based assays and transferred NOE (trNOE) experiments. Some of the compounds showed better activity than sLe(x) in the P-selectin assay.

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Citations

Oct 9, 2002·Medicinal Research Reviews·Neelu Kaila, Bert E Thomas
Oct 22, 2003·Current Opinion in Structural Biology·Carol Beth Post
Jul 12, 2011·Chemical Communications : Chem Comm·Christine WiebeTill Opatz
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor TvaroškaJaroslav Koča
Jun 4, 2014·Chemistry, an Asian Journal·Claudine SchlemmerTill Opatz
Feb 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhui WuShiqi Peng
Feb 17, 2007·Journal of Medicinal Chemistry·Remo KranichEwald M Aydt
Nov 11, 2003·Journal of Combinatorial Chemistry·Roland E Dolle
Jan 5, 2007·Journal of Medicinal Chemistry·Neelu KailaQin Wang
May 26, 2004·Archives of Biochemistry and Biophysics·John L Magnani

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