Beta-carbolines as specific inhibitors of cyclin-dependent kinases

Bioorganic & Medicinal Chemistry Letters
Yongcheng SongMui Mui Sim

Abstract

Harmine (3), 7-fluoro-1-methyl beta-carboline (35) and 1-(5-methyl-imidazol-4-yl) beta-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases. The degree of aromaticity of the tricyclic ring and the positioning of substituents are important for inhibitory activity. While most beta-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) beta-carbolines.

References

Oct 1, 1995·Mutation Research·C de Meester
Oct 1, 1994·The Journal of Pharmacy and Pharmacology·A Fernández de ArribaM Unzeta
Jan 1, 1995·Trends in Biochemical Sciences·J Lew, J H Wang
Jan 1, 1997·Archives of Biochemistry and Biophysics·H KimR R Ramsay
Jan 1, 1997·Annual Review of Cell and Developmental Biology·D O Morgan
Dec 28, 1999·Bioorganic & Medicinal Chemistry Letters·J IshidaK H Lee
Jan 14, 2000·Journal of Medicinal Chemistry
Jan 14, 2000·Journal of Medicinal Chemistry·T M SieleckiG L Trainor
Mar 4, 2000·Journal of the National Cancer Institute·A M Senderowicz, E A Sausville

❮ Previous
Next ❯

Citations

May 22, 2013·European Journal of Medicinal Chemistry·Guoxian ZhangZhenghua Ren
Mar 27, 2003·Bioorganic & Medicinal Chemistry Letters·Guoxin ZhuScott A Watkins
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Concha Sanchez-MartinezJill Wagner
May 15, 2013·BMC Research Notes·Maria L AlomarSergio O Angel
Nov 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qin MaWen Chen
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Qi ChenAnlong Xu
Aug 31, 2007·Magnetic Resonance in Chemistry : MRC·D ReymanJ J Camacho
Mar 8, 2014·Beilstein Journal of Organic Chemistry·Suresh Babu MeruvaP K Dubey
Oct 8, 2014·Acta Crystallographica. Section F, Structural Biology Communications·Hua WangHoujin Zhang
Jul 14, 2020·Frontiers in Cellular and Infection Microbiology·Sergio O AngelWilliam J Sullivan
Feb 3, 2021·Journal of Medicinal Chemistry·Aurélien BeatoRomain Haudecoeur
Mar 22, 2021·Bioorganic & Medicinal Chemistry Letters·Xu HuHuiming Hua
Aug 1, 2021·European Journal of Medicinal Chemistry·Bo Luo, Xinqiang Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

© 2022 Meta ULC. All rights reserved