beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells

Free Radical Biology & Medicine
P PalozzaG M Bartoli

Abstract

This is the first report demonstrating a relationship between apoptosis induction and changes of intracellular redox potential in the growth-inhibitory effects of high concentrations of beta-carotene in a tumor cell line. beta-Carotene inhibited the growth of human WiDr colon adenocarcinoma cells in a dose- and time-dependent manner, induced apoptosis, and blocked Bcl-2 expression. These effects were accompanied by an enhanced production of intracellular reactive oxygen species (ROS). The addition of the antioxidant alpha-tocopherol blocked both the pro-oxidant and the growth-inhibitory effects of the carotenoid. These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties.

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Citations

Dec 19, 2003·Free Radical Biology & Medicine·Hong ZhangAkihiko Nagao
Oct 31, 2003·Molecular Aspects of Medicine·Paola PalozzaGabriella Calviello
Jun 14, 2003·Pharmacology & Therapeutics·L ReddyK D Bhoola
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Aug 25, 2004·Archives of Biochemistry and Biophysics·Paola PalozzaGabriella Calviello
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Sep 3, 2009·Annals of the New York Academy of Sciences·Sung Hee JangHyeyoung Kim
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