Sep 1, 1977

Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases

Archives of Dermatology
Micheline M Mathews-RothE H Kass


We treated with high doses of oral beta carotene (Solatene) (15 to 180 mg/day) 133 patients suffering from erythropoietic protoporphyria (EPP), 27 patients with polymorphous light eruption, six patients with solar urticaria, three patients with hydroa aestivale, one patient with porphyria cutanea tarda, and two patients with actinic reticuloid to relieve the photosensitivity associated with these diseases. Eighty-four percent of the patients with erythropoietic protoporphyria increased by a factor of 3 or more their ability to tolerate sunlight. On the other hand, only nine of the patients with polymorphous light eruption, and one fifth of the patients with all of the other forms of photosensitivity treated showed similar improvement. We conclude that beta carotene is an effective treatment for EPP, but that other forms of photosensitivity will need empirical therapeutic study with beta carotene to determine the range of effectiveness, if any, of this compound in conditions other than EPP.

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Mentioned in this Paper

Erythropoietic Protoporphyria
Hydroa Estivale
Beta Carotene Measurement
Disorders of Porphyrin Metabolism
UROD gene
Polymorphous Light Eruption
Photosensitivity Disorders
Hydroa Vacciniforme
Beta Carotene

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