Beta-casein-based nanovehicles for oral delivery of chemotherapeutic drugs: drug-protein interactions and mitoxantrone loading capacity

Nanomedicine : Nanotechnology, Biology, and Medicine
Alina ShapiraYoav D Livney

Abstract

Beta-casein (beta-CN), a major milk protein, is amphiphilic and self-associates into micelles in aqueous solutions. We have recently introduced a novel oral drug delivery system based on beta-CN nanoparticles. The current research builds on and complements this work by studying the interactions of mitoxantrone (MX) and beta-CN as they co-assemble into nanoparticles, using absorption and emission spectra, static and dynamic light scattering, and fluorescent emission of both MX and tryptophan 143 (Trp143) of beta-CN. The optimal loading molar ratio was 3.3 MX/beta-CN at 1 mg/mL beta-CN, and the association constant was (2.45 +/- 1.76) x 10(5) M(-1) based on beta-CN Trp143 fluorescence; independent MX fluorescence results provided supporting values. In these conditions a bimodal particle distribution was obtained (174.4 nm, 45.9%; 485.1 nm, 54.1%). The gastric digestibility of beta-CN suggests possible targeting to stomach tumors. Hence, beta-CN nanoparticles have potential to serve as effective vehicles of hydrophobic drugs for oral delivery preparations. From the clinical editor: Beta-casein (b-CN) is an amphiphilic milk protein that self-associates into micelles in aqueous solutions and can be utilized as a novel oral drug deli...Continue Reading

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Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Alina ShapiraYoav D Livney

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Citations

May 9, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyNazik A Elgindy
Feb 23, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyNazik A Elgindy
Aug 26, 2015·Therapeutic Delivery·Sara SalatinKhosro Adibkia
Nov 19, 2014·Cell Biochemistry and Biophysics·Adeleh DivsalarFaizan Ahmad
Sep 14, 2013·Colloids and Surfaces. B, Biointerfaces·Mahdieh RazmiHassan Mansuri-Torshizi
Aug 21, 2013·Advanced Drug Delivery Reviews·Yoav D Livney, Yehuda G Assaraf
Jan 17, 2015·Colloids and Surfaces. B, Biointerfaces·Marilene EstanqueiroJosé Manuel Sousa Lobo
Nov 17, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alina ShapiraYoav D Livney
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