Beta-cell autoantibodies and their function in Taiwanese children with type 1 diabetes mellitus

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Yi-Ching TungWen-Yu Tsai

Abstract

To understand the importance of autoimmunity in the development of type 1 diabetes in Taiwanese children, we evaluated the presence of beta-cell autoantibodies and their correlation with residual beta-cell function. From 1989 to 2006, 157 Taiwanese children with newly diagnosed type 1 diabetes were enrolled in this study. We determined the presence of beta-cell autoantibodies, such as glutamic acid decarboxylase autoantibodies (GADAs), insulinoma antigen 2 autoantibodies (IA-2As), and insulin autoantibodies (IAAs). A 6-minute glucagon test was also performed at diagnosis. At diagnosis, 73% of children tested positive for GADAs, 76% for IA-2As and 21% for IAAs. Ninety-two percent of them had at least one of the beta-cell autoantibodies detected. Positivity for IAAs was more frequent in patients younger than 5 years than in those older than 5 years (45% vs. 13%). Using multiple regression analysis, the presence of GADAs or IAAs, or age of onset of these patients was an independent factor for residual beta-cell function. Younger patients and those with GADAs had less residual beta-cell function at disease onset, whereas those with IAAs had more insulin reserve. Autoimmunity plays an important role in the pathogenesis of type 1 dia...Continue Reading

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Citations

Aug 16, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Chen ChenWen-Yu Tsai
Jun 20, 2012·Human Reproduction Update·E CodnerM Tena-Sempere
Sep 26, 2012·Journal of Internal Medicine·C-H Lin, W H-H Sheu
Jul 10, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Noura Al-HassaniWalid Kaplan
Jan 1, 2018·Journal of Receptor and Signal Transduction Research·Armando Ruiz-HernándezSantiago Villafaña
Aug 19, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Daniel ZamanfarMahila Monajati
Aug 14, 2015·Clinical and Experimental Hypertension : CHE·R Romero-NavaS Villafaña
Jul 15, 2021·Journal of Diabetes Research·Kun LinQiong Zeng

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