Beta-cell dysfunction in first-degree relatives of patients with non-insulin-dependent diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
M Fernández-CastañerJ Soler

Abstract

To analyse the relationship between age, glucose tolerance, beta-cell function, and insulin sensitivity in preclinical states of non-insulin-dependent (Type 2) diabetes mellitus (NIDDM), we have done a cross-sectional, age-stratified analysis of 86 non-diabetic first-degree relatives of NIDDM patients and 49 controls with similar age, sex, and BMI. A 5 mg kg ideal body weight-1 min-1 for 60 min of continuous infusion of glucose with model assessment (CIGMA) of serum glucose and C-peptide values at the end of the infusion was used to determine glucose tolerance and beta-cell function. Insulin sensitivity was estimated by modelling basal serum glucose and insulin values. Relatives and controls were divided into tertiles on the basis of age. Relatives had higher basal (5.3 vs 5 mmol l-1, p = 0.02) and achieved serum glucose (9.1 vs 8.4 mmol l-1, p = 0.01), lower beta-cell function (128 vs 145%, p = 0.007), and lower insulin sensitivity (37 vs 43%, p = 0.002). Beta-cell function declined with age in relatives (from 139% in young subjects to 134% in intermediate subjects and to 111% in older subjects, p = 0.002) and this decline was associated with an increase in basal serum glucose (from 5.1 to 5.3 and to 5.7 mmol l-1, p = 0.000) a...Continue Reading

Citations

Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Allan Vaag, Søren S Lund
Jun 28, 2002·Diabetes·Christine C JensenUNKNOWN American Diabetes Association GENNID Study Group
Nov 13, 2009·Diabetes Care·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Oct 30, 2014·Diabetes/metabolism Research and Reviews·Yumei YangJinchao Zhang
Sep 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·A VaagUNKNOWN European Group of Insulin Resistance
Apr 22, 2010·American Journal of Physiology. Endocrinology and Metabolism·Flemming Dela, Bente Stallknecht

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