PMID: 6987115Apr 1, 1980Paper

Beta-cell electrical activity in response to high glucose concentration

Diabetes
P M Beigelman, B Ribalet

Abstract

Glucose-induced beta-cell electrical activity, recorded with glass microelectrodes, is characterized by trains of fast action potentials ("spikes"). The membrane depolarizes before each train of spikes and then repolarizes. This pattern is termed a "burst." There is a characteristic biphasic response to a square wave of 11.1 mM glucose. Pulses at higher glucose concentrations (22.2 mM or more) evoke transient, constant spike activity. The duration of this activity is lengthened and the lag period shortened in proportion to the concentration and length of the glucose pulse. The lag period between removal of glucose and the cessation of spike activity is also proportional to the glucose concentration.

Citations

Jul 4, 2006·Biophysical Journal·Craig S NunemakerLeslie S Satin
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Richard BertramLeslie S Satin

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.