PMID: 344114Jan 1, 1978

beta-cell function in children with diabetes

J Ludvigsson, L Heding


Although it is generally believed that insulin secretion is minimal or absent in juvenile-onset diabetes, we have found appreciable levels of C-peptide at the time of onset in 12 patients, 4 to 16 years old (9.3 +/- 4.2). Ten of them had ketonuria but none severe ketoacidosis. All entered a remission period. Most of the patients had near normal C-peptide levels during the remission, and their beta cells had the capacity to respond to a breakfast stimulation with increased insulin secretion. C-peptide and proinsulin were also determined in 98 juvenile diabetics with age at onset of 1 to 16 years (6.8 +/- 3.9) and a duration of diabetes between two and 17 years (6.7 +/- 3.4). Many were found to have persisting beta-cell function, which seems to be of importance for ensuring stability in metabolic control. Although little is known about factors that may slow or reverse the process leading to beta-cell failure, our results suggest that early detection and intensive treatment of diabetes before severe metabolic disturbances have occurred may help preserve beta-cell function.


Apr 18, 2001·Diabetes/metabolism Research and Reviews·J LudvigssonL Stenhammar
Oct 1, 1979·Acta diabetologica latina·J Ludvigsson, Y Larsson
Oct 1, 1982·Acta diabetologica latina·J Ludvigsson, L Heding
Jan 1, 1979·Irish Journal of Medical Science·J G DevlinV Parameswaran
May 1, 1983·Irish Journal of Medical Science·O J Hensey, C S Smith
Mar 1, 1980·The Journal of Pediatrics·M MenchiniG Chiumello
Jun 1, 1980·Australian Paediatric Journal·B A DarlowD W Beaven
Jun 1, 1982·Archives of Disease in Childhood·N P Mann, D I Johnston
Mar 23, 1999·Archives of Disease in Childhood·B J MuhammadJ L Botha
Jan 15, 1983·British Medical Journal·J LudvigssonA Lernmark
Feb 28, 2015·Pediatric Diabetes·Linda A DiMeglioDiabetes Research in Children Network (DirecNet); Type 1 Diabetes TrialNet Study Group
Jan 1, 1991·Diabetes Research and Clinical Practice·J J CouperL C Harrison
Nov 1, 1988·Acta paediatrica Scandinavica·G DahlquistS Wall
Feb 1, 1982·Australian and New Zealand Journal of Medicine·C GlatthaarE A Espiner
Jul 1, 1987·Acta paediatrica Scandinavica·S A IvarssonJ I Thorell
Nov 1, 1982·Acta paediatrica Scandinavica·M KnipH K Akerblom
Mar 1, 1982·Acta paediatrica Scandinavica·H B MortensenK W Kastrup
Feb 11, 2010·Journal of Diabetes Science and Technology·J Ludvigsson, Linköping Diabetes Immune Intervention Study Group
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb
Jan 21, 2011·Physiological Reviews·Tom L van BelleMatthias G von Herrath
Nov 30, 2000·Upsala Journal of Medical Sciences·F A KarlssonL Zhao
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·J Ludvigsson
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·S Madsbad
Sep 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johnna D WesleyDaniel J Campbell
Jul 1, 1981·Annals of Clinical Biochemistry·A M Bonser, P Garcia-Webb

Related Concepts

Metabolic Process, Cellular
Insulin C-peptide Measurement
Cancer Remission
Diabetes Mellitus, Insulin-Dependent

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.