Abstract
It is a common belief that early atherosclerosis in prediabetes is causally linked to endothelial insulin resistance. Another condition, a low insulin secretion, may be associated with insufficient insulin action on the vascular wall and consequently favor atherosclerosis. Our aim was to test this hypothesis in people without diabetes, taking into account the gold-standard measurement of insulin sensitivity, a major confounder in the relationship between insulin secretion and atherosclerosis. We studied the European Relationship between Insulin Sensitivity and Cardiovascular Risk cohort of 451 men and 593 women (44 ± 8 years, mean ± SD) who were free of diabetes, hypertension, dyslipidemia, and other known chronic or acute conditions. All underwent an oral glucose tolerance test, a euglycemic-hyperinsulinemic clamp (M/I measured insulin sensitivity), and B-mode carotid ultrasound. Intima-media thickness (IMT) in the common carotid artery was negatively associated with insulin secretion indexes, with Spearman partial correlation coefficients: -0.09, -0.08, -0.06 for respectively, the disposition index, the early insulin response and the beta cell glucose sensitivity, after adjusting for established factors, including clamp-measu...Continue Reading
References
Sep 1, 1994·Diabetologia·C D ByrneC N Hales
Oct 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·N J WarehamC N Hales
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·S D KantersJ D Banga
Aug 17, 1999·The Journal of Clinical Investigation·Z Y JiangG L King
Sep 10, 1999·Diabetes Care·M Matsuda, R A DeFronzo
Dec 14, 2001·Nature·M Brownlee
Apr 12, 2002·Endocrine Reviews·Gary F LewisAdria Giacca
May 25, 2002·European Journal of Clinical Investigation·G Boden, G I Shulman
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Andrea MariEle Ferrannini
Oct 1, 2003·Circulation·Andreas FestaSteven M Haffner
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Hillevi LarssonBo Ahrén
Feb 18, 2004·Diabetologia·S A HillsUNKNOWN Report prepared on behalf of the EGIR-RISC Study Group
Apr 19, 2006·Circulation·Jeong-a KimMichael J Quon
Feb 14, 2008·Journal of Atherosclerosis and Thrombosis·Tetsuro MiyazakiHiroyuki Daida
Jun 9, 2009·The New England Journal of Medicine·UNKNOWN BARI 2D Study GroupBurton E Sobel
Nov 17, 2009·Stroke; a Journal of Cerebral Circulation·Joseph F PolakDaniel H O'Leary
Dec 29, 2009·Atherosclerosis·Hsiu-Fen LinSuh-Hang H Juo
Mar 13, 2010·Diabetologia·A MariUNKNOWN RISC Investigators
May 7, 2010·Cell Metabolism·Christian Rask-MadsenGeorge L King
Jul 9, 2010·Lancet·UNKNOWN Emerging Risk Factors CollaborationJ Danesh
Oct 27, 2011·Diabetes·Andrea MariUNKNOWN RISC Investigators
Jun 13, 2012·The New England Journal of Medicine·Hertzel C GersteinSalim Yusuf
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Ajay ChaudhuriVivian Fonseca
Aug 23, 2012·JAMA : the Journal of the American Medical Association·Hester M Den RuijterMichiel L Bots
Apr 9, 2013·Diabetes Care·Eva M LonnUNKNOWN GRACE and ORIGIN Investigators
Apr 20, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Michaela KozakovaUNKNOWN RISC Investigators
May 4, 2013·European Heart Journal·Francesco PaneniFrancesco Cosentino
Jul 25, 2013·Atherosclerosis·F AndreozziF Perticone
Aug 15, 2013·Diabetologia·Fabrice BonnetUNKNOWN DESIR and RISC Study Groups
Jan 28, 2015·Hypertension·Anouk L M EikendalUNKNOWN USE-IMT Project Group
Citations
Jun 4, 2016·Diabetes & Metabolism·F BonnetA Natali
Mar 30, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Yu-Hsuan LiJun-Sing Wang
Dec 10, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ZhouY Wang
Sep 29, 2017·Stroke; a Journal of Cerebral Circulation·Yuesong PanYilong Wang
Apr 30, 2017·Aging·Alexander FedintsevAlexey Moskalev
Jan 2, 2021·Scientific Reports·Elko RandrianarisoaMartin Heni
May 15, 2021·Stroke; a Journal of Cerebral Circulation·Takuya KiyoharaUNKNOWN FSR Investigators
Nov 9, 2021·Cardiovascular Drugs and Therapy·Xiliang ZhaoYong Zeng