Beta-cell function recovery is not the only factor responsible for remission in type I diabetics: evaluation of C-peptide secretion in diabetic children after first metabolic recompensation and at partial remission phase

Journal of Endocrinological Investigation
E SchoberM Fink

Abstract

In 9 newly diagnosed type I diabetic children the residual beta-cell secretory capacity was examined after stimulation with oral glucose load, glucagon and iv glucose plus arginine hydrochloride administration shortly after diagnosis and in the partial remission phase. A significant C-peptide secretion induced by these substances except by iv glucose was found at both investigation times. Whereas beta-cell function did only slightly increase from the initial testing to the measurements in the partial remission, beta-cell sensitivity increased significantly (p less than 0.05). The data suggest that "partial remission" referred to C-peptide secretion starts very early after insulin treatment and that other factors, possibly a decrease of peripheral insulin resistance, are involved in the improved metabolic control in partial remission phase.

References

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Citations

Jul 12, 2002·Diabetes/metabolism Research and Reviews·Carla J Greenbaum
Mar 18, 2006·Diabetes/metabolism Research and Reviews·Roberto Mallone, Paolo Cavallo Perin
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·N C SchlootT Mandrup-Poulsen
Nov 6, 2007·Nature Reviews. Immunology·Matthias von HerrathKevan Herold

Related Concepts

Teens
Arginine hydrochloride
C-Peptide
Diabetes, Autoimmune
Glucagon
Intravenous Glucose Tolerance Test
Insulin B Chain
Islets of Langerhans

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