Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

Diabetologia
L PascoeRISC Consortium

Abstract

Novel type 2 diabetes-susceptibility loci have been identified with evidence that individually they mediate the increased diabetes risk through altered pancreatic beta cell function. The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals. A total of 1,211 non-diabetic individuals underwent metabolic assessment including an OGTT, from which measures of beta cell function were derived. Individuals were genotyped at each of the risk loci and then classified according to the total number of risk alleles that they carried. Initial analysis focused on CDKAL1, HHEX/IDE and TCF7L2 loci, which were individually associated with a decrease in beta cell function in our cohort. Risk alleles for CDKN2A/B, SLC30A8, IGF2BP2 and KCNJ11 loci were subsequently included into the analysis. The diabetes-risk alleles for CDKAL1, HHEX/IDE and TCF7L2 showed an additive model of association with measures of beta cell function. Beta cell glucose sensitivity was decreased by 39% in those individuals with five or more risk alleles compared with those individuals with no risk alleles (geometric mean [SEM]: 84 [1.07] vs 137 [1.11] pmol min(-1) m(-2) (mmol/l)(-1), p = 1.5...Continue Reading

References

Apr 27, 2007·Nature Genetics·Valgerdur SteinthorsdottirKari Stefansson
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
Aug 3, 2007·The Journal of Clinical Investigation·Valeriya LyssenkoLeif Groop

❮ Previous
Next ❯

Citations

Sep 17, 2009·Diabetologia·M StadlerUNKNOWN RISC Investigators
Oct 5, 2010·Current Diabetes Reports·Niels GrarupTorben Hansen
May 22, 2010·The British Journal of Nutrition·Clive J Petry
Oct 13, 2009·Diabetes, Obesity & Metabolism·G LeibowitzE Cerasi
Feb 12, 2011·Diabetologia·A M C Simonis-BikE M W Eekhoff
Sep 29, 2011·Metabolism: Clinical and Experimental·Andrea TuraAndrea Mari
Feb 2, 2011·The Medical Clinics of North America·Ele FerranniniPatricia Iozzo
Mar 10, 2009·Diabetes/metabolism Research and Reviews
Aug 17, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·K G BrodoviczC J Girman
Apr 7, 2011·Journal of Diabetes Investigation·Gil LeibowitzErol Cerasi
Oct 18, 2012·Islets·Piero MarchettiLorella Marselli
Mar 5, 2009·The Journal of Clinical Endocrinology and Metabolism·Axel HauptHans-Ulrich Häring
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Jeannet LauenborgTorben Hansen
Aug 19, 2021·Journal of the Endocrine Society·Hironobu SasakiHiroshi Itoh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.