Beta-Cell Replacement: Pancreas and Islet Cell Transplantation

Endocrine Development
Nadja NiclaussThierry Berney

Abstract

Pancreas and islet transplantation are 2 types of beta-cell replacement therapies for type 1 diabetes mellitus. Since 1966, when pancreas transplantation was first performed, it has evolved to become a highly efficient procedure with high success rates, thanks to advances in surgical technique and immunosuppression. Pancreas transplantation is mostly performed as simultaneous pancreas-kidney transplantation in patients with end-stage nephropathy secondary to diabetes. In spite of its efficiency, pancreas transplantation is still a major surgical procedure burdened by high morbidity, which called for the development of less invasive and hazardous ways of replacing beta-cell function in the past. Islet transplantation was developed in the 1970s as a minimally invasive procedure with initially poor outcomes. However, since the report of the 'Edmonton protocol' in 2000, the functional results of islet transplantation have substantially and constantly improved and are about to match those of whole pancreas transplantation. Islet transplantation is primarily performed alone in nonuremic patients with severe hypoglycemia. Both pancreas transplantation and islet transplantation are able to abolish hypoglycemia and to prevent or slow do...Continue Reading

Citations

Nov 29, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Youakim SalibaNassim Farès
Dec 7, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Raphael P H MeierLeo H Buhler
Jun 4, 2016·Current Opinion in Organ Transplantation·Steven A WiselPeter G Stock
Aug 28, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Charles-Henri WassmerEkaterine Berishvili
Aug 21, 2019·Cell Transplantation·Andrew T CraneWalter C Low
Aug 28, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Raphael P H MeierThierry Berney
Jul 10, 2020·Stem Cell Research & Therapy·Shuai ChenChunlin Zou
Sep 9, 2017·Transplantation·Christian SchuetzUNKNOWN IPITA YIC Young Investigator Committee
Oct 8, 2020·Médecine sciences : M/S·Fanny LebretonEkaterine Berishvili
Dec 2, 2020·Biomedicines·Shoichiro Sumi
Dec 29, 2020·Transplantation Direct·Julie De BeuleLaurens J Ceulemans

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