PMID: 9546813Jan 1, 1997Paper

Beta-cell rest: a strategy for the prevention of autoimmune diabetes

Autoimmunity
F A Karlsson, E Björk

Abstract

An autoantigen being recognized by specific receptors is the key reaction of an autoimmune disease. Whereas much efforts have been made to develop immunosuppressive regimens which reduce the amount of effector cells, and/or inhibit receptor activation, surprisingly little attention has been paid to reduce the ligand-receptor interaction by interfering with the amount of antigen being presented from the target cells. In this review, we discuss clinical observations in autoimmune endocrine disease which illustrate that target cell alterations can modify the disease activity and comment on recent clinical trials which indicate that beta-cell rest may be beneficial to the course of human autoimmune diabetes mellitus.

References

Dec 1, 1992·Clinical and Experimental Immunology·H GisslingerM Weissel
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z J ZhangH L Weiner
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B H TohD C Humphris
May 11, 1991·BMJ : British Medical Journal·R D Leslie, D A Pyke
Jun 1, 1990·Diabetes Care·L RossettiR A DeFronzo
Nov 1, 1986·Pflügers Archiv : European journal of physiology·G TrubeT Ohno-Shosaku
Mar 2, 1989·The New England Journal of Medicine·S C ShahN E Simpson
Nov 1, 1986·The Journal of Clinical Endocrinology and Metabolism·P BurmanF A Karlsson
Aug 1, 1986·World Journal of Surgery·P N GoodeJ A Morte
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·R JanssonF A Karlsson
Jan 31, 1987·British Medical Journal·K BuschardC Kühl
Mar 21, 1987·British Medical Journal·R Hall, J H Lazarus
Jun 16, 1988·The New England Journal of Medicine·M B AtkinsM M Kaplan
May 22, 1986·The New England Journal of Medicine·G S Eisenbarth
Jul 27, 1968·Lancet·A HernandezH Gershberg
Apr 8, 1982·The New England Journal of Medicine·N AminoK Miyai

❮ Previous
Next ❯

Citations

Feb 18, 2011·Langenbeck's Archives of Surgery·Leif JanssonOrjan Källskog
Mar 19, 1999·Journal of Internal Medicine·A SchölinE Björk
May 7, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E StrandellK Bendtzen
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·N C SchlootT Mandrup-Poulsen
Oct 14, 2005·Diabetes/metabolism Research and Reviews·Beate KargesWolfram Karges
Jan 29, 2008·Pediatric Diabetes·Rebecca J Brown, Kristina I Rother
Nov 30, 2000·Upsala Journal of Medical Sciences·F A KarlssonL Zhao
May 22, 2002·Annals of the New York Academy of Sciences·Jerry P Palmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.