Beta-endorphin concentrations in brain areas and peritoneal macrophages in rats susceptible and resistant to experimental allergic encephalomyelitis: a possible relationship between tumor necrosis factor alpha and opioids in the disease

Journal of Neuroimmunology
A E PaneraiP Sacerdote

Abstract

Since the central nervous system and neuropeptides modulate immune functions, we investigated whether the different susceptibility of Lewis and Brown Norway rats to experimental allergic encephalomyelitis could also reflect differences in beta-endorphin and substance P concentrations in brain areas and macrophages during the development of the disease. We show that beta-endorphin concentrations increase much more in the hypothalamus and macrophages of Lewis rats during the development of the disease, while the increase is much lower or absent in Brown Norway rats. Tumor necrosis factor-alpha seems to play an important role in this difference. The administration of the opiate receptor antagonist naltrexone worsens the development of the disease, suggesting that the increase of the opioid beta-endorphin might represent a mechanism to downregulate the immune response. In both strains, the concentrations of substance P do not change.

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Citations

Jul 17, 1999·Journal of Neuroimmunology·P SacerdoteA E Panerai
Jan 15, 2000·Journal of Neuroimmunology·J A MoynihanR Ader
Jul 23, 1999·Annals of the New York Academy of Sciences·P SacerdoteA E Panerai
Feb 26, 2004·Arthritis Research & Therapy·I-Chuan ChuangLin-Cheng Yang
Oct 25, 2011·Experimental Parasitology·Ali Gorgin Karaji, Yazdan Hamzavi
Mar 28, 2001·Annals of the New York Academy of Sciences·P SacerdoteA E Panerai
Dec 23, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·UNKNOWN ALSUntangled Group
May 12, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·UNKNOWN ALSUntangled Group

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